Tan Lingling, Ji Guiyi, Bao Ting, Fu Hongbo, Yang Ling, Yang Ming
Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Health Management Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Insights Imaging. 2021 Nov 6;12(1):163. doi: 10.1186/s13244-021-01106-2.
Measuring muscle mass and muscle quality based on chest Computed Tomography (CT) images would facilitate sarcopenia and myosteatosis research. We aimed (1) to measure muscle mass and myosteatosis based on chest CT images at the 12 thoracic vertebra level and compare the relevant indicators with whole-body skeletal muscle mass (BSM) and whole-body fat mass (BFM) measured by bioelectrical impedance analysis; and (2) to determine the cut-off points of these indicators for diagnosing sarcopenia or myosteatosis in healthy Chinese adults.
Chest CT images were analyzed using a segmentation software. Skeletal muscle area (SMA), skeletal muscle radiodensity (SMD), and intermuscular adiposity tissue (IMAT) were measured. Skeletal muscle indices (SMIs) and IMAT/SMA ratio were calculated.
We included 569 participants. SMA, SMA/height, and SMA/BMI were strongly and positively correlated with BSM (r = 0.90, 0.72, and 0.69, respectively, all p < 0.001); whereas SMA/weight was moderately and positively correlated with BSM (r = 0.38, p < 0.001). IMAT and IMAT/SMA were strongly and positively correlated with BFM (r = 0.67 and 0.58, respectively, both p < 0.001). SMD was moderately and negatively correlated with BFM (r = - 0.40, p < 0.001). We suggest SMA/height (< 25.75 cm/m in men and < 20.16 cm/m in women) for diagnosing sarcopenia and SMD (< 37.42 HU in men and < 33.17 HU in women) or IMAT (> 8.72 cm in men and > 4.58 cm in women) for diagnosing myosteatosis.
Muscle mass indicators (SMA and SMIs) and muscle quality indicators (SMD, IMAT, and IMAT/SMA) measured by chest CT images are valuable for diagnosing sarcopenia and myosteatosis, respectively.
基于胸部计算机断层扫描（CT）图像测量肌肉质量和肌肉质量有助于肌肉减少症和肌少性肥胖症的研究。我们旨在：（1）基于第12胸椎水平的胸部CT图像测量肌肉质量和肌少性肥胖症，并将相关指标与通过生物电阻抗分析测量的全身骨骼肌质量（BSM）和全身脂肪质量（BFM）进行比较；（2）确定这些指标在诊断健康中国成年人肌肉减少症或肌少性肥胖症时的截断点。
使用分割软件分析胸部CT图像。测量骨骼肌面积（SMA）、骨骼肌放射密度（SMD）和肌间脂肪组织（IMAT）。计算骨骼肌指数（SMIs）和IMAT/SMA比值。
我们纳入了569名参与者。SMA、SMA/身高和SMA/体重指数与BSM呈强正相关（r分别为0.90、0.72和0.69，均p<0.001）；而SMA/体重与BSM呈中度正相关（r=0.38，p<0.001）。IMAT和IMAT/SMA与BFM呈强正相关（r分别为0.67和0.58，均p<0.001）。SMD与BFM呈中度负相关（r=-0.40，p<0.001）。我们建议，诊断肌肉减少症采用SMA/身高（男性<25.75cm/m，女性<20.16cm/m），诊断肌少性肥胖症采用SMD（男性<37.42HU，女性<33.17HU）或IMAT（男性>8.72cm，女性>4.58cm）。
通过胸部CT图像测量的肌肉质量指标（SMA和SMIs）和肌肉质量指标（SMD、IMAT和IMAT/SMA）分别对诊断肌肉减少症和肌少性肥胖症具有重要价值。
