土壤来源真菌W1-1产生的抗微生物天然产物
Antimicrobial Natural Products Produced by Soil-Derived Fungus W1-1.
作者信息
Sang Xu-Yan, Wang Zhao-Jie, Yang Ya-Bin, Wang Yong-Liang, Xiang Mei-Ling, Zhu Dou-Ying, Zhou Ying, Luo Xiao-Dong, Zhao Li-Xing
机构信息
Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of EducationYunnan Research & Development Center for Natural ProductsSchool of Chemical Science and Technology, Yunnan University, Kunming, 650091 P. R. China.
College of Life Science, Yunnan Institute of Microbiology, Yunnan University, 650091 Kunming, P. R. China.
出版信息
Indian J Microbiol. 2021 Dec;61(4):519-523. doi: 10.1007/s12088-021-00957-z. Epub 2021 Jun 20.
Ten compounds (-) were obtained from soil-derived W1-1 with the antimicrobial guided isolation procedure. Among them, presented broad-spectrum antimicrobial activities and its preliminary mechanisms were evaluated. Compound showed growth inhibition on drug-resistant pathogenic strains and with post-contact effect (PCE), changed the morphology and membrane structure, killed cells with leakage, inhibited the growth of by eradicating biofilms. Interestingly, the fraction containing presented in vivo anti-pathogenic activities in mice, indicating this indole diterpenoid alkaloid could been used as potential antimicrobial agent.
通过抗菌导向分离程序从土壤来源的W1-1中获得了十种化合物（-）。其中，呈现出广谱抗菌活性并对其初步机制进行了评估。化合物对耐药病原菌和表现出生长抑制作用，并具有接触后效应（PCE），改变了形态和膜结构，导致细胞死亡并伴有泄漏，通过消除生物膜抑制的生长。有趣的是，含有该化合物的组分在小鼠体内呈现出抗病原活性，表明这种吲哚二萜生物碱可作为潜在的抗菌剂。
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