Paraherquamide J，一种新型的来源于海洋真菌 HK1-6 的prenylated indole alkaloid。
Paraherquamide J, a new prenylated indole alkaloid from the marine-derived fungus HK1-6.
机构信息
Key Laboratory of Marine Drugs, the Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China.
Marine Science & Technology Institute, College of Environmental Science & Engineering, Yangzhou University, Yangzhou City, Jiangsu Province, People's Republic of China.
出版信息
Nat Prod Res. 2020 Feb;34(3):378-384. doi: 10.1080/14786419.2018.1534105. Epub 2019 Jan 9.
A new prenylated indole alkaloid, named paraherquamide J (), together with four known compounds (-), were isolated from the mangrove rhizosphere soil-derived fungus HK1-6. The planar structure and relative configuration of were determined by detailed analysis of the spectroscopic data especially the NOESY spectrum. The absolute configuration of was determined by ECD spectra. Compound was first isolated as a natural product and named as paraherquamide K. All isolated metabolites were evaluated for their antibacterial, topoisomerase I (topo I) inhibitory activities and lethality towards brine shrimp .
一种新的prenylated indole alkaloid，命名为paraherquamide J (), 与四个已知化合物 (-) 一起从红树林根际土壤衍生的真菌 HK1-6 中分离得到。通过详细分析光谱数据，特别是 NOESY 谱，确定了的平面结构和相对构型。的绝对构型通过 ECD 光谱确定。化合物 作为天然产物首次分离得到，并命名为 paraherquamide K。所有分离得到的代谢产物均进行了抗菌、拓扑异构酶 I（topo I）抑制活性和对卤虫致死性的评价。
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