基因多态性对非霍奇金淋巴瘤风险及临床结局的影响
The Influence of Gene Polymorphisms on the Risk and Clinical Outcome of Non-Hodgkin Lymphoma.
作者信息
Mousa Somaia Mohammed, Makhlouf Manal Mohamed, Mohammed Ekhlass Talaat, Zawam Hamdy Mohamed
机构信息
Clinical Pathology Department, Kasr Al-Ainy School of Medicine, Cairo University, Cairo, 11562 Egypt.
Egyptian Ministry of Health, Cairo, Egypt.
出版信息
Indian J Hematol Blood Transfus. 2021 Oct;37(4):549-554. doi: 10.1007/s12288-020-01388-4. Epub 2021 Jan 4.
Polymorphisms in the gene are associated with various diseases and cancers including non-Hodgkin lymphoma (NHL). The aim of the study is to assess the impact of genetic polymorphisms [- 330 T/G (rs2069762) and + 114 T/G (rs2069763)] on the susceptibility and prognosis of NHL. Sixty patients with NHL as well as 60 age and sex matched healthy control subjects are included in this study. genotypes were determined by Polymerase Chain Reaction-Restriction Fragment length Polymorphism assay (PCR-RFLP). Our study revealed that both rs2069762 and rs2069763 gene polymorphisms are associated with increased risk of developing NHL; OR = 3.609 (95% CI = 1.527-8.417) and 4.142 (95% CI = 1.637-10.538) respectively. Moreover, the simultaneous presence of both polymorphisms is associated with about 6 fold increased risk of developing NHL. Also, rs2069762 and rs2069763 gene polymorphisms increase the risk of unfavorable prognosis with OR = 17.300 (95% CI = 3.392-87.725) and 10.424(95% CI = 1.870-58.413) respectively. These findings suggest that (rs2069762) and (rs2069763) gene polymorphisms could be involved in the development of NHL.
该基因的多态性与包括非霍奇金淋巴瘤（NHL）在内的多种疾病和癌症相关。本研究的目的是评估[ - 330 T/G（rs2069762）和 + 114 T/G（rs2069763）]基因多态性对NHL易感性和预后的影响。本研究纳入了60例NHL患者以及60例年龄和性别匹配的健康对照者。通过聚合酶链反应 - 限制性片段长度多态性分析（PCR - RFLP）确定基因型。我们的研究表明，rs2069762和rs2069763基因多态性均与发生NHL的风险增加相关；OR分别为3.609（95% CI = 1.527 - 8.417）和4.142（95% CI = 1.637 - 10.538）。此外，两种多态性同时存在与发生NHL的风险增加约6倍相关。同样，rs2069762和rs2069763基因多态性分别使不良预后风险增加，OR分别为17.300（95% CI = 3.392 - 87.
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