Department of Internal Medicine, Emergency Center, Shanghai East Hospital, Tongji University, Shanghai, China.
DNA Cell Biol. 2012 Jul;31(7):1279-84. doi: 10.1089/dna.2011.1603. Epub 2012 Apr 3.
Non-Hodgkin lymphoma (NHL) is the most common hematologic malignancy worldwide. Interleukin-2 (IL-2) plays a key role in the proliferation of T cells and natural killer cells. It has been reported that polymorphisms in the IL-2 gene are associated with various cancers. The aim of this study was to examine the effect of polymorphisms in the IL-2 gene on the development of NHL in the Chinese population. IL-2-330T/G and +114T/G polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism in 438 NHL cases and 482 age-matched healthy controls. Data were analyzed using the Chi-square test. Results showed that individuals with -330TG genotype or -330GG genotype had significantly increased susceptibility to NHL (Odds ratio [OR] = 1.40, 95% confidence interval [CI]: 1.05-1.85, p = 0.020 and OR = 2.04, 95%CI: 1.28-3.24, p = 0.002). Meanwhile, the +114T/G polymorphism did not show any correlation with NHL. When analyzing the haplotypes of these two polymorphisms, the prevalence of -330G/+114T haplotype was significantly higher in NHL cases than in controls (OR = 1.45, 95%CI: 1.12-1.88, p = 0.005). These data indicate that IL-2 gene polymorphisms may be new risk factors for NHL.
非霍奇金淋巴瘤（NHL）是全球最常见的血液系统恶性肿瘤。白细胞介素-2（IL-2）在 T 细胞和自然杀伤细胞的增殖中发挥关键作用。据报道，IL-2 基因的多态性与各种癌症有关。本研究旨在探讨 IL-2 基因多态性对中国人群 NHL 发病的影响。采用聚合酶链反应-限制性片段长度多态性检测 438 例 NHL 病例和 482 例年龄匹配的健康对照者的 IL-2-330T/G 和+114T/G 多态性。采用卡方检验进行数据分析。结果显示，-330TG 基因型或-330GG 基因型个体患 NHL 的风险显著增加（比值比 [OR] = 1.40，95%置信区间 [CI]：1.05-1.85，p = 0.020 和 OR = 2.04，95%CI：1.28-3.24，p = 0.002）。同时，+114T/G 多态性与 NHL 无相关性。分析这两个多态性的单倍型时，NHL 病例中-330G/+114T 单倍型的患病率明显高于对照组（OR = 1.45，95%CI：1.12-1.88，p = 0.005）。这些数据表明，IL-2 基因多态性可能是 NHL 的新危险因素。
