Fukushima S, Shibata M, Tamano S, Ito N, Suzuki E, Okada M
J Natl Cancer Inst. 1987 Aug;79(2):263-7.
The effect of age on induction of carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine [(BBN) CAS: 3817-11-6] in the urinary bladder epithelium was examined in 130 male and 130 female F344 rats. Rats of both sexes 6, 52, and 98 weeks old were given 0.025% BBN in their drinking water for 20 weeks. Then approximately half the rats were sacrificed, while the rest were maintained without further treatment for 10 weeks. Examination of the rats revealed an age-related increase in the induction of urinary bladder carcinoma, although the total intakes of BBN and urinary excretions of its proximate carcinogen were not age related. Rats treated with BBN at 98 weeks of age developed more squamous cell carcinomas and invasive carcinomas than the 2 younger groups. This study demonstrated an increased risk of urinary bladder carcinogenesis with age in animals.
在130只雄性和130只雌性F344大鼠中，研究了年龄对N-丁基-N-(4-羟基丁基)亚硝胺[(BBN)，CAS: 3817-11-6]诱导膀胱上皮细胞癌变的影响。6周龄、52周龄和98周龄的雌雄大鼠饮用含0.025%BBN的饮用水20周。然后大约一半的大鼠被处死，其余的大鼠在不进行进一步治疗的情况下维持10周。对大鼠的检查显示，尽管BBN的总摄入量及其近致癌物的尿排泄量与年龄无关，但膀胱癌的诱导与年龄相关。98周龄接受BBN治疗的大鼠比2个较年轻的组发生更多的鳞状细胞癌和浸润性癌。这项研究表明，动物中膀胱癌发生的风险随年龄增加。
