Tautvydaitė Domilė, Adam-Darqué Alexandra, Manuel Aurélie L, Ptak Radek, Schnider Armin
Laboratory of Cognitive Neurorehabilitation, Division of Neurorehabilitation, Department of Clinical Neuroscience, University Hospital and University of Geneva, Geneva, Switzerland.
Front Behav Neurosci. 2021 Oct 22;15:684647. doi: 10.3389/fnbeh.2021.684647. eCollection 2021.
The medial temporal lobe (MTL) is crucial for memory encoding and recognition. The time course of these processes is unknown. The present study juxtaposed encoding and recognition in a single paradigm. Twenty healthy subjects performed a continuous recognition task as brain activity was monitored with a high-density electroencephalography. The task presented New pictures thought to evoke encoding. The stimuli were then repeated up to 4 consecutive times to produce over-familiarity. These repeated stimuli served as "baseline" for comparison with the other stimuli. Stimuli later reappeared after 9-15 intervening items, presumably associated with new encoding and recognition. Encoding-related differences in evoked response potential amplitudes and in spatiotemporal analysis were observed at 145-300 ms, whereby source estimation indicated MTL and orbitofrontal activity from 145 to 205 ms. Recognition-related activity evoked by late repetitions occurred at 405-470 ms, implicating the MTL and neocortical structures. These findings indicate that encoding of information is initiated before it is recognized. The result helps to explain modifications of memories over time, including false memories, confabulation, and consolidation.
内侧颞叶（MTL）对记忆编码和识别至关重要。这些过程的时间进程尚不清楚。本研究在单一范式中并列了编码和识别过程。20名健康受试者执行了一项连续识别任务，同时用高密度脑电图监测大脑活动。该任务呈现被认为会引发编码的新图片。然后将这些刺激连续重复多达4次，以产生过度熟悉感。这些重复的刺激作为与其他刺激进行比较的“基线”。刺激随后在9 - 15个中间项目之后再次出现，大概与新的编码和识别相关。在145 - 300毫秒时观察到诱发反应电位振幅以及时空分析中与编码相关的差异，由此源估计表明在145至205毫秒时MTL和眶额部有活动。后期重复诱发的与识别相关的活动出现在405 - 470毫秒，涉及MTL和新皮质结构。这些发现表明信息的编码在其被识别之前就已开始。该结果有助于解释记忆随时间的变化，包括错误记忆、虚构和巩固。
