Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD 20892, USA.
Medical Scientist Training Program, Duke University School of Medicine, Durham, NC 27710, USA.
Science. 2020 Mar 6;367(6482):1131-1134. doi: 10.1126/science.aba0672.
Episodic memory retrieval is thought to rely on the replay of past experiences, yet it remains unknown how human single-unit activity is temporally organized during episodic memory encoding and retrieval. We found that ripple oscillations in the human cortex reflect underlying bursts of single-unit spiking activity that are organized into memory-specific sequences. Spiking sequences occurred repeatedly during memory formation and were replayed during successful memory retrieval, and this replay was associated with ripples in the medial temporal lobe. Together, these data demonstrate that human episodic memory is encoded by specific sequences of neural activity and that memory recall involves reinstating this temporal order of activity.
情景记忆检索被认为依赖于对过去经历的回放，但目前尚不清楚在情景记忆编码和检索过程中，人类单个单元活动是如何在时间上组织的。我们发现，人类大脑皮层中的涟漪振荡反映了单个单元尖峰活动的潜在爆发，这些爆发被组织成特定于记忆的序列。在记忆形成过程中，尖峰序列反复出现，并在成功的记忆检索过程中被回放，而这种回放与内侧颞叶的涟漪有关。总之，这些数据表明，人类情景记忆是通过特定的神经活动序列进行编码的，而记忆回忆涉及到恢复这种活动的时间顺序。
