Gjerde Priyanthi B, Simonsen Carmen E, Lagerberg Trine V, Steen Nils Eiel, Andreassen Ole A, Steen Vidar M, Melle Ingrid
Norwegian Centre for Mental Disorders Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Dr. Einar Martens Research Group for Biological Psychiatry, Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway.
Front Psychiatry. 2021 Oct 21;12:723158. doi: 10.3389/fpsyt.2021.723158. eCollection 2021.
Schizophrenia is a disorder with considerable heterogeneity in course and outcomes, which is in part related to the patients' sex. Studies report a link between serum lipids, body mass index (BMI), and therapeutic response. However, the role of sex in these relationships is poorly understood. In a cross-sectional sample of first-episode psychosis (FEP) patients, we investigated if the relationship between serum lipid levels (total cholesterol, HDL-C, LDL-C, and triglycerides), BMI, and symptoms differs between the sexes. We included 435 FEP patients (males: = 283, 65%) from the ongoing Thematically Organized Psychosis (TOP) study. Data on clinical status, antipsychotics, lifestyle, serum lipid levels, and BMI were obtained. The Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS) were used to assess psychotic and depressive symptoms. General linear models were employed to examine the relationship between metabolic variables and symptomatology. We observed a female-specific association between serum HDL-C levels and negative symptoms ( = -2.24, = 0.03) and between triglycerides levels ( = 1.48, = 0.04) and BMI ( = 0.27, = 0.001) with depressive symptoms. When controlling for BMI, only the association between serum HDL-C levels and negative symptoms remained significant. Moreover, the HDL-C and BMI associations remained significant after controlling for demography, lifestyle, and illness-related factors. We found a relationship between metabolic factors and psychiatric symptoms in FEP patients that was sex-dependent.
精神分裂症是一种在病程和预后方面具有显著异质性的疾病，这部分与患者的性别有关。研究报告了血清脂质、体重指数（BMI）与治疗反应之间的联系。然而，性别在这些关系中的作用却鲜为人知。在首次发作精神病（FEP）患者的横断面样本中，我们调查了血清脂质水平（总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯）、BMI与症状之间的关系在性别上是否存在差异。我们纳入了正在进行的主题性组织精神病（TOP）研究中的435例FEP患者（男性：=283例，65%）。获取了关于临床状态、抗精神病药物、生活方式、血清脂质水平和BMI的数据。使用阳性和阴性症状量表（PANSS）和卡尔加里精神分裂症抑郁量表（CDSS）来评估精神病性症状和抑郁症状。采用一般线性模型来检验代谢变量与症状学之间的关系。我们观察到血清高密度脂蛋白胆固醇水平与阴性症状之间存在女性特异性关联（=-2.24，=0.03），甘油三酯水平（=1.48，=0.04）与BMI（=0.27，=0.001）与抑郁症状之间存在女性特异性关联。在控制BMI后，只有血清高密度脂蛋白胆固醇水平与阴性症状之间的关联仍然显著。此外，在控制人口统计学、生活方式和疾病相关因素后，高密度脂蛋白胆固醇与BMI之间的关联仍然显著。我们发现FEP患者中代谢因素与精神症状之间存在性别依赖性关系。
