• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

泛影葡胺（Gastrografin®）对斑马鱼阿片类药物诱导的便秘模型的促动力作用。

Prokinetic effects of diatrizoate meglumine (Gastrografin®) in a zebrafish for opioid-induced constipation model.

作者信息

Kim Dongwoo, Koun Soonil, Kim Seung Young, Ha Young Ran, Choe Jung Wan, Jung Sung Woo, Hyun Jong Jin, Jung Young Kul, Koo Ja Seol, Yim Hyung Joon, Lee Sang Woo

机构信息

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Seoul, Republic of Korea.

Biochemical Research Center, Korea University Ansan Hospital, Ansan, Republic of Korea.

出版信息

Anim Cells Syst (Seoul). 2021 Oct 25;25(5):264-271. doi: 10.1080/19768354.2021.1991472. eCollection 2021.

DOI:10.1080/19768354.2021.1991472
PMID:34745433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8567942/
Abstract

Constipation is a common disease that reduces life quality. Drugs of various mechanisms are being developed to resolve this affliction. Intestinal motility can be easily monitored in zebrafish, and so we selected this organism to develop a constipation model to measure drug-induced prokinetic effects. In this study, intestinal motility was monitored in zebrafish by tracking intestinal transit using fluorescence, after which an opioid-induced constipation model was established using loperamide. We then evaluated the prokinetic effect of diatrizoate meglumine (Gastrografin®), which has been empirically used to treat post-operative ileus or adhesive small bowel obstructions. Diatrizoate meglumine was effective in promoting bowel movements in an opioid-induced zebrafish constipation model and its prokinetic effect was associated with an increased expression of interstitial cells of Cajal (ICC) markers. Therefore, the loperamide-induced zebrafish constipation model developed herein is a promising tool to evaluate novel constipation therapies.

摘要

便秘是一种降低生活质量的常见疾病。目前正在研发各种作用机制的药物来解决这一困扰。斑马鱼的肠道蠕动很容易监测，因此我们选择这种生物来建立便秘模型，以测量药物诱导的促动力效应。在本研究中，通过荧光追踪肠道转运来监测斑马鱼的肠道蠕动，之后使用洛哌丁胺建立阿片类药物诱导的便秘模型。然后，我们评估了泛影葡胺（Gastrografin®）的促动力作用，该药物已被经验性地用于治疗术后肠梗阻或粘连性小肠梗阻。泛影葡胺在阿片类药物诱导的斑马鱼便秘模型中能有效促进肠道蠕动，其促动力作用与 Cajal 间质细胞（ICC）标志物表达增加有关。因此，本文建立的洛哌丁胺诱导的斑马鱼便秘模型是评估新型便秘治疗方法的一个有前景的工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3181/8567942/ae21e18283f1/TACS_A_1991472_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3181/8567942/7b52e4dddd1a/TACS_A_1991472_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3181/8567942/123b90de44b0/TACS_A_1991472_F0002_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3181/8567942/dbb7f3e1f9a9/TACS_A_1991472_F0003_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3181/8567942/7d89b00595a2/TACS_A_1991472_F0004_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3181/8567942/ae21e18283f1/TACS_A_1991472_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3181/8567942/7b52e4dddd1a/TACS_A_1991472_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3181/8567942/123b90de44b0/TACS_A_1991472_F0002_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3181/8567942/dbb7f3e1f9a9/TACS_A_1991472_F0003_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3181/8567942/7d89b00595a2/TACS_A_1991472_F0004_OB.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3181/8567942/ae21e18283f1/TACS_A_1991472_F0005_OC.jpg

相似文献

1
Prokinetic effects of diatrizoate meglumine (Gastrografin®) in a zebrafish for opioid-induced constipation model.泛影葡胺（Gastrografin®）对斑马鱼阿片类药物诱导的便秘模型的促动力作用。
Anim Cells Syst (Seoul). 2021 Oct 25;25(5):264-271. doi: 10.1080/19768354.2021.1991472. eCollection 2021.
2
A retrospective audit on usage of Diatrizoate Meglumine (Gastrografin) for intestinal obstruction or constipation in patients with advanced neoplasms.回顾性分析对比晚期肿瘤患者使用泛影葡胺（胃影葡胺）治疗肠梗阻或便秘的效果。
Palliat Med. 2018 Jan;32(1):294-298. doi: 10.1177/0269216317726430. Epub 2017 Aug 14.
3
Use of gastrografin in the management of faecal impaction in patients with severe chronic constipation: a randomized clinical trial.泛影葡胺在重度慢性便秘患者粪便嵌塞管理中的应用：一项随机临床试验。
ANZ J Surg. 2019 Mar;89(3):239-243. doi: 10.1111/ans.14863. Epub 2018 Oct 8.
4
Manipulation of intestinal dysbiosis by a bacterial mixture ameliorates loperamide-induced constipation in rats.细菌混合物通过操纵肠道菌群失调改善洛哌丁胺诱导的大鼠便秘。
Benef Microbes. 2018 Apr 25;9(3):453-464. doi: 10.3920/BM2017.0062. Epub 2018 Apr 10.
5
[Therapeutic effect and mechanism of Shouhui Tongbian Capsules on slow transit constipation model mice].寿惠通便胶囊对慢传输型便秘模型小鼠的治疗作用及机制
Zhongguo Zhong Yao Za Zhi. 2021 Feb;46(3):520-525. doi: 10.19540/j.cnki.cjcmm.20201125.401.
6
Possible adverse effect of methylglucamine diatrizoate compounds on the bowel of newborn infants with meconium ileus.泛影葡胺化合物对患有胎粪性肠梗阻的新生儿肠道可能产生的不良反应。
Radiology. 1976 Dec;121(3 Pt. 1):693-6. doi: 10.1148/121.3.693.
7
Electroacupuncture via chronically implanted electrodes improves gastrointestinal motility by balancing sympathovagal activities in a rat model of constipation.慢性植入电极的电针通过平衡便秘大鼠模型中的交感副交感活动来改善胃肠动力。
Am J Physiol Gastrointest Liver Physiol. 2019 Jun 1;316(6):G797-G805. doi: 10.1152/ajpgi.00018.2018. Epub 2019 Mar 28.
8
Prokinetic agents for lower gastrointestinal motility disorders.用于下消化道动力障碍的促动力剂。
Dis Colon Rectum. 1993 Jul;36(7):696-708. doi: 10.1007/BF02238599.
9
Amelioration of gut dysbiosis and gastrointestinal motility by konjac oligo-glucomannan on loperamide-induced constipation in mice.魔芋低聚糖改善洛哌丁胺诱导的小鼠便秘引起的肠道菌群失调和胃肠动力障碍。
Nutrition. 2020 May;73:110715. doi: 10.1016/j.nut.2019.110715. Epub 2019 Dec 23.
10
Therapeutic effect of oral Gastrografin in adhesive, partial small-bowel obstruction: a prospective randomized trial.口服泛影葡胺治疗粘连性部分小肠梗阻的疗效：一项前瞻性随机试验。
Surgery. 1994 Apr;115(4):433-7.

引用本文的文献

1
Effect of Probiotics in Stress-Associated Constipation Model in Zebrafish () Larvae.益生菌对斑马鱼（）幼鱼应激相关便秘模型的影响。
Int J Mol Sci. 2024 Mar 25;25(7):3669. doi: 10.3390/ijms25073669.
2
Effects of black garlic on the pacemaker potentials of interstitial cells of Cajal in murine small intestine and on gastrointestinal motility .黑蒜对小鼠小肠中Cajal间质细胞的起搏电位及胃肠动力的影响。
Anim Cells Syst (Seoul). 2022 Mar 10;26(1):37-44. doi: 10.1080/19768354.2022.2049640. eCollection 2022.

本文引用的文献

1
Capsaicin suppresses liver fat accumulation in high-fat diet-induced NAFLD mice.辣椒素可抑制高脂饮食诱导的非酒精性脂肪性肝病（NAFLD）小鼠的肝脏脂肪堆积。
Anim Cells Syst (Seoul). 2020 Aug 26;24(4):214-219. doi: 10.1080/19768354.2020.1810771.
2
Utility of animal gastrointestinal motility and transit models in functional gastrointestinal disorders.动物胃肠道动力和传输模型在功能性胃肠疾病中的应用。
Best Pract Res Clin Gastroenterol. 2019 Jun-Aug;40-41:101633. doi: 10.1016/j.bpg.2019.101633. Epub 2019 Jul 26.
3
G2019s LRRK2 promotes mitochondrial fission and increases TNFα-mediated neuroinflammation responses.
G2019s型亮氨酸丰富重复激酶2（LRRK2）促进线粒体分裂并增强肿瘤坏死因子α（TNFα）介导的神经炎症反应。
Anim Cells Syst (Seoul). 2019 Mar 1;23(2):106-111. doi: 10.1080/19768354.2019.1585948. eCollection 2019 Apr.
4
Pathophysiology, diagnosis, and management of opioid-induced constipation.阿片类药物所致便秘的病理生理学、诊断和治疗。
Lancet Gastroenterol Hepatol. 2018 Mar;3(3):203-212. doi: 10.1016/S2468-1253(18)30008-6.
5
Chronic constipation: A review of literature.慢性便秘：文献综述
Medicine (Baltimore). 2018 May;97(20):e10631. doi: 10.1097/MD.0000000000010631.
6
Chronic constipation in the elderly: a primer for the gastroenterologist.老年慢性便秘：胃肠病学家入门指南
BMC Gastroenterol. 2015 Oct 14;15:130. doi: 10.1186/s12876-015-0366-3.
7
Acetylcholine serves as a derepressor in Loperamide-induced Opioid-Induced Bowel Dysfunction (OIBD) in zebrafish.乙酰胆碱在洛哌丁胺诱导的斑马鱼阿片类药物引起的肠功能障碍（OIBD）中起去阻遏物的作用。
Sci Rep. 2014 Jul 7;4:5602. doi: 10.1038/srep05602.
8
Zebrafish model in drug safety assessment.斑马鱼模型在药物安全性评估中的应用
Curr Pharm Des. 2014;20(34):5416-29. doi: 10.2174/1381612820666140205145658.
9
Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2013 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group.博洛尼亚黏连性小肠梗阻（ASBO）诊断和治疗指南：世界急诊外科学会 ASBO 工作组基于循证医学的 2013 年更新指南。
World J Emerg Surg. 2013 Oct 10;8(1):42. doi: 10.1186/1749-7922-8-42.
10
The zebrafish reference genome sequence and its relationship to the human genome.斑马鱼参考基因组序列及其与人类基因组的关系。
Nature. 2013 Apr 25;496(7446):498-503. doi: 10.1038/nature12111. Epub 2013 Apr 17.