Farraj Yousef, Buxboim Amnon, Cohen Jose E, Kan-Tor Yoav, Glasner Hagege Shira, Weiss Dor, Goldman Vladimir, Beatus Tsevi
Casali Center for Applied Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
Equally contributed.
Biomed Opt Express. 2021 Sep 22;12(10):6485-6495. doi: 10.1364/BOE.435508. eCollection 2021 Oct 1.
Monitoring pupillary size and light-reactivity is a key component of the neurologic assessment in comatose patients after stroke or brain trauma. Currently, pupillary evaluation is performed manually at a frequency often too low to ensure timely alert for irreversible brain damage. We present a novel method for monitoring pupillary size and reactivity through closed eyelids. Our method is based on side illuminating in near-IR through the temple and imaging through the closed eyelid. Successfully tested in a clinical trial, this technology can be implemented as an automated device for continuous pupillary monitoring, which may save staff resources and provide earlier alert to potential brain damage in comatose patients.
监测瞳孔大小和光反应性是中风或脑外伤后昏迷患者神经学评估的关键组成部分。目前，瞳孔评估是手动进行的，频率往往过低，无法确保对不可逆脑损伤及时发出警报。我们提出了一种通过闭合眼睑监测瞳孔大小和反应性的新方法。我们的方法基于通过颞部进行近红外侧照光，并透过闭合的眼睑进行成像。该技术已在一项临床试验中成功测试，可以作为一种用于持续瞳孔监测的自动化设备来实施，这可能节省工作人员资源，并为昏迷患者潜在的脑损伤提供更早的警报。
