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由聚（N-乙烯基吡咯烷酮）和聚乙烯醇改性的多糖逐层膜。

Layer-by-layer films of polysaccharides modified with poly(N-vinylpyrrolidone) and poly(vinyl alcohol).

作者信息

Livanovich Kanstantsin S, Sharamet Anastasiya A, Shimko Anna N, Shutava Tatsiana G

机构信息

Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, Minsk, Belarus.

Center for Analytical Spectral Measurements, B.I. Stepanov Institute of Physics, National Academy of Sciences of Belarus, Minsk, Belarus.

出版信息

Heliyon. 2021 Oct 21;7(10):e08224. doi: 10.1016/j.heliyon.2021.e08224. eCollection 2021 Oct.

DOI:10.1016/j.heliyon.2021.e08224
PMID:34746473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8555284/
Abstract

N-grafted copolymers of chitosan (460 kDa) with poly(N-vinylpyrrolidone) (2.4 kDa) or poly(vinyl alcohol) (2.0 ​kDa) as side chains were synthesized. Depending on the polymer-to-chitosan mass ratio the degree of amino group substitution with side chains in chitosan backbone was varied in the range of 0.01-0.33. Layer-by-layer films consisted of copolymers and dextran sulfate as polyanion were obtained. Thickness, hydrophilicity, and morphology of the films were investigated using QCM, UV-vis spectrophotometry, AFM, and contact angle measurements. The obtained films show enhanced protein-repellent properties in fetal bovine serum medium. The mass of adsorbed proteins on LbL films based on copolymer with a degree of substitution of 0.2 decreases by 50 ​% compared to unmodified chitosan. Protein-repellent properties of copolymer-based films are common for LbL films of grafted chitosan copolymers and depend on hydrophilic side chain density on the surface.

摘要

合成了壳聚糖（460 kDa）与聚（N-乙烯基吡咯烷酮）（2.4 kDa）或聚乙烯醇（2.0 kDa）作为侧链的N-接枝共聚物。根据聚合物与壳聚糖的质量比，壳聚糖主链中侧链对氨基的取代度在0.01 - 0.33范围内变化。获得了由共聚物和作为聚阴离子的硫酸葡聚糖组成的层层膜。使用石英晶体微天平（QCM）、紫外可见分光光度法、原子力显微镜（AFM）和接触角测量对膜的厚度、亲水性和形态进行了研究。所得薄膜在胎牛血清培养基中显示出增强的抗蛋白质吸附性能。与未改性的壳聚糖相比，基于取代度为0.2的共聚物的层层膜上吸附蛋白质的质量减少了50%。基于共聚物的薄膜的抗蛋白质吸附性能是接枝壳聚糖共聚物层层膜所共有的，并且取决于表面亲水性侧链密度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/a87281aa6765/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/8eb8e87e8e5f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/a3afc9d08728/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/ce95a674c5a2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/c18dab23d26c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/f898881ae25d/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/bf7581f2173b/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/2fe5359788f7/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/a87281aa6765/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/8eb8e87e8e5f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/a3afc9d08728/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/ce95a674c5a2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/c18dab23d26c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/f898881ae25d/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/bf7581f2173b/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/2fe5359788f7/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce2a/8555284/a87281aa6765/gr8.jpg

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