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VIII族金属羰基簇-硼酸共轭物：细胞毒性及作用机制研究

Group VIII Metal Carbonyl Cluster-Boronic Acid Conjugates: Cytotoxicity and Mode of Action Studies.

作者信息

Kong Jia Wen, Lam Zhiyong, Chan Kiat Hwa, Ganguly Rakesh, Joey Lee Jia-Ying, Loo Lit-Hsin, Webster Richard D, Wong Zhen Xuan, Leong Weng Kee

机构信息

Division of Chemistry and Biological Chemistry, School of Mathematical and Physical Sciences, Nanyang Technological University, Singapore 637371, Singapore.

Yale-NUS College, 16 College Avenue West, Singapore 138527, Singapore.

出版信息

ACS Omega. 2021 Oct 22;6(43):29045-29053. doi: 10.1021/acsomega.1c04116. eCollection 2021 Nov 2.

DOI:10.1021/acsomega.1c04116
PMID:34746593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8567370/
Abstract

A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os(CO)(μ-H)[μ-SCH--B(OH)]} () could be chemically oxidized to its hydroxy analogue [Os(CO)(μ-H)(μ-SCH -OH)] (), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death.

摘要

合成了一组第VIII族金属（铁、钌和锇）的金属羰基簇-硼酸共轭物，并测定了它们对两种乳腺癌细胞系（MCF-7和MDA-MB-231）以及一种非癌性乳腺上皮（MCF-10A）细胞系的抗增殖作用。对于MDA-MB-231细胞，细胞毒性遵循Ru>Os>Fe的顺序，尽管后两者对MCF-7和MCF-10A细胞表现出相似的细胞毒性。锇物种{Os(CO)(μ-H)[μ-SCH--B(OH)]}（）可以化学氧化为其羟基类似物[Os(CO)(μ-H)(μ-SCH -OH)]（），后者表现出相当的细胞毒性。作用机制研究表明细胞死亡是通过凋亡途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cc/8567370/2015819a1cc4/ao1c04116_0007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cc/8567370/308b68269826/ao1c04116_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cc/8567370/dfede2951b6c/ao1c04116_0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cc/8567370/5ed753b86932/ao1c04116_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cc/8567370/a869393d22ae/ao1c04116_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cc/8567370/4528fd6388f9/ao1c04116_0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cc/8567370/23130a069e29/ao1c04116_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cc/8567370/6e6d2872af4d/ao1c04116_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16cc/8567370/2015819a1cc4/ao1c04116_0007.jpg

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