SPICA：瑞士免疫细胞分析门户。

SPICA: Swiss portal for immune cell analysis.

机构信息

Ludwig Institute for Cancer Research, Lausanne Branch, and Department of Oncology, CHUV and University of Lausanne, Epalinges 1066, Switzerland.

Swiss Institute of Bioinformatics, Lausanne, Switzerland.

出版信息

Nucleic Acids Res. 2022 Jan 7;50(D1):D1109-D1114. doi: 10.1093/nar/gkab1055.

DOI:10.1093/nar/gkab1055

PMID:34747477

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8728228/

Abstract

Single-cell transcriptomics allows the study of immune cell heterogeneity at an unprecedented level of resolution. The Swiss portal for immune cell analysis (SPICA) is a web resource dedicated to the exploration and analysis of single-cell RNA-seq data of immune cells. In contrast to other single-cell databases, SPICA hosts curated, cell type-specific reference atlases that describe immune cell states at high resolution, and published single-cell datasets analysed in the context of these atlases. Additionally, users can privately analyse their own data in the context of existing atlases and contribute to the SPICA database. SPICA is available at https://spica.unil.ch.

摘要

单细胞转录组学允许以前所未有的分辨率研究免疫细胞异质性。瑞士免疫细胞分析门户（SPICA）是一个专门用于探索和分析免疫细胞单细胞 RNA-seq 数据的网络资源。与其他单细胞数据库不同，SPICA 提供了经过精心整理的、细胞类型特异性的参考图谱，这些图谱以高分辨率描述了免疫细胞状态，以及在这些图谱背景下分析的已发表单细胞数据集。此外，用户可以在现有的图谱背景下对自己的数据进行私人分析，并为 SPICA 数据库做出贡献。SPICA 可在 https://spica.unil.ch 上获得。