Finseth F, Adelberg M G
Plast Reconstr Surg. 1978 May;61(5):738-43. doi: 10.1097/00006534-197805000-00013.
Large island skin flaps, comprising the entire abdominal covering in rats, were raised on one neurovascular pedicle in the groin. A standard area of necrosis was produced on the other side from the pedicle. However, when the animals were treated with certain vasodilator drugs for 15 days before and 7 days after the flaps were raised, there was little or no necrosis. The effect of the drug therapy was the same as a surgical delay.
在大鼠身上，以腹股沟处的一条神经血管蒂掀起覆盖整个腹部的大岛状皮瓣。在蒂的另一侧制造一个标准面积的坏死区。然而，若在掀起皮瓣前15天及掀起后7天用某些血管扩张剂药物治疗动物，几乎没有或没有坏死现象。药物治疗的效果与手术延迟相同。
