Ankara University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey.
J Trace Elem Med Biol. 2022 Jan;69:126894. doi: 10.1016/j.jtemb.2021.126894. Epub 2021 Nov 4.
Safe exposure levels for industrial chemicals are a prerequisite to the safety of workers in occupational settings.
The application areas of the benchmark dose (BMD) approach have tremendously increased in recent years. Quantitative analyzes of dose-response relationships of genotoxic chemicals are among these application areas too. This study investigates the applicability of sister chromatid exchange (SCE) frequencies in lymphocytes of lead-exposed workers to derive a biological limit value (BLV) for inorganic lead. To this end, our previously published occupational lead exposure data were pooled and re-examined by using the BMD approach. Subsequently, we determined the point of departure (POD) value for lead-induced SCE frequencies in lymphocytes. Accordingly, the blood lead concentrations and SCE frequencies in lymphocytes of 26 control and 108 lead-exposed male voluntary workers employed in a battery manufacturing plant were subjected to BMD modeling to determine the BMD confidence interval (BMD-CI).
According to our data set, benchmark dose lower bound (BMDL) of 6.55 μg Pb/dL blood for the SCE frequencies in lymphocytes of lead-exposed workers has been obtained.
The blood lead concentration of 6.55 μg/dL might be proposed as the BLV for lead and its inorganic lead compounds based on our dataset.
工业化学品的安全暴露水平是职业环境中工人安全的前提。
近年来，基准剂量 (BMD) 方法的应用领域有了极大的增加。对遗传毒性化学品的剂量-反应关系进行定量分析就是这些应用领域之一。本研究调查了淋巴细胞姐妹染色单体交换 (SCE) 频率在推断无机铅的生物限值 (BLV) 方面的适用性。为此，我们汇集并重新使用 BMD 方法分析了先前发表的职业性铅暴露数据。随后，我们确定了铅诱导的淋巴细胞 SCE 频率的起始点 (POD) 值。相应地，我们对 26 名对照和 108 名从事电池制造工厂工作的男性自愿暴露于铅的男性工人的血液铅浓度和淋巴细胞 SCE 频率进行了 BMD 建模，以确定 BMD 置信区间 (BMD-CI)。
根据我们的数据集，获得了暴露于铅的工人淋巴细胞 SCE 频率的基准剂量下限 (BMDL) 为 6.55μg Pb/dL 血液。
根据我们的数据集，血液铅浓度 6.55μg/dL 可能被提议为铅及其无机铅化合物的 BLV。
