Saphier D, Abramsky O, Mor G, Ovadia H
Ann N Y Acad Sci. 1987;496:354-9. doi: 10.1111/j.1749-6632.1987.tb35787.x.
In order to examine possible neurophysiological changes during an immune response, we have recorded neural activity in a conscious animal bearing chronic recording electrodes in the preoptic area/anterior hypothalamus (PO/AH) and hypothalamic paraventricular nucleus (PVN). Male rats were sensitized with sheep red blood cells (SRBC) injected intraperitoneally. Basal PO/AH multiunit activity (MUA) was recorded as 14.7 +/- 2.1 Hz prior to sensitization and was seen to increase significantly to a maximum of 33.1 +/- 6.0 Hz (p less than 0.005) five days after SRBC injection. This increase correlated with the initial appearance of anti-SRBC serum antibodies at a mean antibody titer of 1:32. Also recorded were decreases in PO/AH MUA on days 3 and 8 after the sensitization (8.2 +/- 2.4 Hz, p less than 0.005); 7.1 +/- 3.3 Hz, p less than 0.005, respectively). Basal PVN MUA was recorded as 14.7 +/- 2.4 Hz. It decreased significantly for the first three days after immunization, and then returned to a basal rate before increasing to 25.9 +/- 8.4 Hz (p less than 0.005) on day 6. On the ninth and tenth days after SRBC injection PO/AH and PVN MUA levels returned to those recorded before immunization.
为了研究免疫反应过程中可能出现的神经生理变化，我们记录了一只清醒动物的神经活动，该动物在视前区/下丘脑前部（PO/AH）和下丘脑室旁核（PVN）植入了慢性记录电极。雄性大鼠通过腹腔注射绵羊红细胞（SRBC）进行致敏。致敏前记录的基础PO/AH多单位活动（MUA）为14.7±2.1Hz，在注射SRBC五天后显著增加至最大值33.1±6.0Hz（p<0.005）。这种增加与抗SRBC血清抗体最初出现时平均抗体滴度为1:32相关。还记录到致敏后第3天和第8天PO/AH的MUA下降（分别为8.2±2.4Hz，p<0.005；7.1±3.3Hz，p<0.005）。基础PVN的MUA记录为14.7±2.4Hz。免疫后的前三天显著下降，然后恢复到基础水平，在第6天增加到25.9±8.4Hz（p<0.005）。在注射SRBC后的第9天和第10天，PO/AH和PVN的MUA水平恢复到免疫前记录的水平。
