Schaible H G, Schmidt R F, Willis W D
Exp Brain Res. 1987;66(3):489-99. doi: 10.1007/BF00270681.
Recordings were made from 16 ascending tract cells in the spinal cords of anaesthetized, spinalized cats before and after an acute arthritis was produced by injection of kaolin and carrageenan into the knee joint. The responses tested routinely were to passive flexion of the knee, an innocuous movement. In some cases, responses to other movements were also tested, and changes in background discharge rates were monitored. Control recordings for a period of 1 h or in 3 cases of 3 h indicated that the responses to flexion were reasonably stationary. Four tract cells that initially showed little or no response to flexion of the knee joint developed large responses within 1 to 2 h after inflammation of the joint. Another 9 cells were tested that had responses to flexion of the knee joint prior to inflammation. In 6 cases, inflammation produced enhanced static or transient responses. In 2 cases, the effect of flexion was initially inhibitory or variable, but after inflammation these cells showed large excitatory responses. In the other case, inflammation had no effect. Background discharges were increased by inflammation in 6 of these 9 cells. The effect of inflammation of the knee joint was tested on 3 tract cells that had no clearly defined receptive field in the knee. In 1 case, a response developed to knee flexion after acute inflammation was produced. In the other 2 cases, there were initially responses to knee flexion, but these were unchanged by inflammation. Two of the cells tested had bilateral receptive fields in or around the knee joints. Inflammation of one knee joint enhanced the responses to flexion of the same but not of the contralateral knee in one case but greatly increased the responses to flexion of both knees in the other case. Injections of prostaglandin (PGE2) caused an enhancement of the responses to knee flexion beyond that caused by inflammation in 5 of 7 cases. One cell whose responses to flexion of the knee were unaffected by inflammation showed inhibitory responses to prostaglandin injections into the inflamed knee joint. The effects of inflammation on the responses of ascending tract cells of the spinal cord appear to serve as a useful neural model of the events responsible for the development of arthritic pain.
在向麻醉的、脊髓横断的猫膝关节内注射高岭土和角叉菜胶诱发急性关节炎之前和之后，对16个脊髓升支束细胞进行了记录。常规测试的反应是对膝关节被动屈曲这种无害运动的反应。在某些情况下，也测试了对其他运动的反应，并监测背景放电率的变化。1小时的对照记录或3例3小时的对照记录表明，对屈曲的反应相当稳定。4个最初对膝关节屈曲几乎没有反应或无反应的束细胞在关节炎症发生后1至2小时内产生了强烈反应。另外9个在炎症发生前对膝关节屈曲有反应的细胞也进行了测试。在6例中，炎症使静态或瞬态反应增强。在2例中，屈曲的效果最初是抑制性的或多变的，但炎症后这些细胞表现出强烈的兴奋性反应。在另一例中，炎症没有影响。这9个细胞中有6个的背景放电因炎症而增加。对3个在膝关节中没有明确界定感受野的束细胞测试了膝关节炎症的影响。在1例中，急性炎症发生后对膝关节屈曲产生了反应。在另外2例中，最初对膝关节屈曲有反应，但炎症对此没有影响。测试的细胞中有2个在膝关节内或周围有双侧感受野。在1例中，一个膝关节的炎症增强了对同侧膝关节屈曲的反应，但对侧膝关节屈曲的反应未增强；而在另一例中，炎症大大增加了对双侧膝关节屈曲的反应。注射前列腺素（PGE2）在7例中有5例使对膝关节屈曲的反应增强程度超过炎症所致。1个对膝关节屈曲的反应不受炎症影响的细胞，对向发炎膝关节注射前列腺素表现出抑制性反应。脊髓升支束细胞反应的炎症效应似乎可作为关节炎疼痛发生相关事件的有用神经模型。
