Engineering Research Center for Biotechnology of Active Substances (Ministry of Education), Chongqing Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing 401331, P.R. China.
Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing 400016, P.R. China.
Nano Lett. 2021 Nov 24;21(22):9433-9441. doi: 10.1021/acs.nanolett.1c02697. Epub 2021 Nov 9.
Drug-resistant pathogenic bacteria as a worldwide health threat calls for valid antimicrobial agents and tactics in clinical practice. Positively charged materials usually achieve antibacteria through binding and disrupting bacterial membranes via electrostatic interaction, however, they also usually cause hemolysis and cytotoxicity. Herein, we engineered negatively charged sulfur quantum dots (SQDs) as an efficient broad-spectrum antibiotic to kill drug-resistant bacteria and . The SQDs can destroy the bacterial membrane system and affect their metabolism due to the intrinsic antibacterial activity of elemental sulfur and catalytic generation of reactive oxygen species, which exhibit effective therapeutic effect on subcutaneously implanted infection model induced by representative pathogenic and . Plus, the negatively charged surface makes the SQDs have excellent hemocompatibility and low toxicity, which all highlight the critical prospect of the SQDs as a potent biocompatible antibacterial agent in clinical infection therapy.
耐药性病原菌对全球健康构成威胁，因此在临床实践中需要有效的抗菌药物和策略。带正电荷的材料通常通过静电相互作用结合并破坏细菌膜来实现抗菌作用，但它们通常也会导致溶血和细胞毒性。在此，我们设计了带负电荷的硫量子点（SQDs）作为一种有效的广谱抗生素，以杀死耐药性细菌和。由于元素硫的固有抗菌活性和活性氧的催化生成，SQDs 可以破坏细菌的膜系统并影响其代谢，对代表性病原菌和引起的皮下植入感染模型表现出有效的治疗效果。此外，负电荷表面使 SQDs 具有优异的血液相容性和低毒性，这都凸显了 SQDs 作为一种有潜力的临床感染治疗用生物相容抗菌剂的重要前景。
