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挽救性部分联合肝脏离断和门静脉结扎的二步肝切除术治疗左半肝切除术后中肝静脉损伤

Rescue Partial ALPPS for Left Hemihepatectomy with Reconstruction of the Middle Hepatic Vein.

机构信息

Department of Hepato-Biliary-Pancreatic Surgery, Kyorin University Hospital, Mitaka-City, Japan.

出版信息

Dig Surg. 2021;38(5-6):325-329. doi: 10.1159/000520695. Epub 2021 Nov 9.

Abstract

Major hepatectomy in patients with insufficient future liver remnant (FLR) volume and impaired liver functional reserve has considerable risks for posthepatectomy liver failure (PHLF). The patient was a male in his 70s with an intrahepatic cholangiocarcinoma in left hemiliver, involving the middle hepatic vein (MHV). Although FLR volume after left hemihepatectomy was estimated to be 64.4% of the total liver volume, an indocyanine green retention rate at 15 min (ICG-R15) value was 24.2%, thus the patient underwent left portal vein embolization. The FLR volume increased to 71.3%; however, the noncongestive FLR volume was re-estimated as 45.8% after resection of the MHV, the ICG-R15 value was 29.0%, and ICG-Krem was calculated as 0.037. We performed partial rescue Associating Liver Partition and Portal vein occlusion for Staged hepatectomy (ALPPS) for left hemihepatectomy with the MHV reconstruction. On the first stage, partial liver partition was done along Rex-Cantlie's line, preserving the MHV and sacrificing the remaining branches to segment 8. The FLR volume increased to 77.4% on day 14. The ICG-R15 value was 29.6%, but ICG-Krem after MHV reconstruction was estimated to be 0.059. The second-stage operation on day 21 was left hemihepatectomy with the MHV reconstruction using the left superficial femoral vein graft. The usage of rescue partial ALPPS may contribute to preventing PHLF by introducing occlusion of the portal and/or venous branches in the left hemiliver before curative hepatectomy.

摘要

在剩余肝体积(FLR)不足和肝功能储备受损的患者中进行大肝切除术,肝切除术后肝衰竭(PHLF)的风险相当大。患者为 70 多岁男性,左半肝内胆管细胞癌,累及中肝静脉(MHV)。虽然左半肝切除术后 FLR 体积估计为总肝体积的 64.4%,但吲哚菁绿 15 分钟滞留率(ICG-R15)值为 24.2%,因此患者接受了左门静脉栓塞术。FLR 体积增加到 71.3%;然而,切除 MHV 后非充血性 FLR 体积重新估计为 45.8%,ICG-R15 值为 29.0%,ICG-Krem 计算为 0.037。我们对 MHV 重建的左半肝切除术进行了部分挽救性联合肝分区和门静脉阻断分期肝切除术(ALPPS)。在第一阶段,沿 Rex-Cantlie 线进行部分肝分区,保留 MHV 并牺牲剩余的 8 段分支。第 14 天 FLR 体积增加到 77.4%。ICG-R15 值为 29.6%,但 MHV 重建后的 ICG-Krem 估计为 0.059。第 21 天的第二阶段手术是使用左股浅静脉移植物进行左半肝切除术和 MHV 重建。在根治性肝切除术前,通过对左半肝门静脉和/或静脉分支进行闭塞,使用挽救性部分 ALPPS 可能有助于预防 PHLF。

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