Timchenko T, Bernardi F
Institut des Sciences du végétal, CNRS, 91198 Gif-sur-Yvette.
Virologie (Montrouge). 2007 Feb 1;11(1):27-42. doi: 10.1684/vir.2011.9629.
Nanoviridae family comprises genus Nanovirus (viruses infecting legume plants) and Babuvirus (viruses infecting banana plants). Nanovirus genomes consist of multiple circular single-stranded DNAs of about 1 kb each. They are encapsidated individually in small icosahedral particles. Each DNA molecule encodes only one protein. Nanoviruses replicate in the nucleus of infected plants by a rolling-circle replication mechanism initiated by viral Rep protein. Multiple DNAs encoding similar but clearly distinct Rep proteins have been described for each nanovirus. All Rep proteins of a given nanovirus are functional and each initiates replication of the DNA by which it is encoded (auto-replication). Only the Master Rep protein is able to initiate replication of other genome components (trans-replication). Induction of nanovirus disease by cloned genome components was established only for Faba bean necrotic yellows virus.
纳米病毒科包括纳米病毒属（感染豆科植物的病毒）和巴布病毒属（感染香蕉植物的病毒）。纳米病毒基因组由多个约1kb的环状单链DNA组成。它们分别被包裹在小的二十面体颗粒中。每个DNA分子仅编码一种蛋白质。纳米病毒通过由病毒Rep蛋白启动的滚环复制机制在受感染植物的细胞核中进行复制。对于每种纳米病毒，已经描述了多个编码相似但明显不同的Rep蛋白的DNA。给定纳米病毒的所有Rep蛋白都具有功能，并且每个都启动其编码的DNA的复制（自我复制）。只有主Rep蛋白能够启动其他基因组组分的复制（反式复制）。仅针对蚕豆坏死黄化病毒确定了由克隆的基因组组分诱导纳米病毒病。
