Department of Hematology, Adana City Research & Training Hospital, Adana, 01170, Turkey.
Department of General Surgery, Faculty of Medicine, Mersin University, Mersin, 33343, Turkey.
Biomark Med. 2022 Feb;16(2):57-67. doi: 10.2217/bmm-2021-0696. Epub 2021 Nov 10.
The aim of this study is to determine whether a novel prognostic score can be obtained by including low muscle mass in the international prognostic score (IPS) system. Psoas muscle areas were determined in the PET/CT scans of the patients taken for staging at the time of diagnosis and after two cycles of ABVD. After evaluating the effect of low muscle mass on overall survival, receiver operating characteristic (ROC) analyzes were performed by including it in IPS systems. Overall survival was significantly lower in patients with low muscle mass. Adding low muscle mass to IPS scores increased AUC, sensitivity and specificity. The integration of low muscle mass into the IPS scoring systems increased the success of these systems in predicting a prognosis.
本研究旨在通过在国际预后评分（IPS）系统中纳入低肌肉量来确定是否可以获得新的预后评分。在诊断时进行分期的 PET/CT 扫描和 ABVD 两个周期后，确定了患者的竖脊肌区域。在评估低肌肉量对总生存的影响后，通过将其纳入 IPS 系统进行了接收者操作特征（ROC）分析。低肌肉量患者的总生存率明显降低。将低肌肉量加入 IPS 评分可提高 AUC、敏感性和特异性。将低肌肉量纳入 IPS 评分系统可提高这些系统预测预后的成功率。
