Department of Infectious Disease, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China.
Department of Infectious Disease, Fujian Medical University Union Hospital, Fuzhou, China.
Sci Rep. 2021 Nov 9;11(1):21964. doi: 10.1038/s41598-021-01570-2.
To investigate the potential prognostic value of Serum cystatin C (sCys C) in patients with COVID-19 and determine the association of sCys C with severe COVID-19 illness. We performed a retrospective review of medical records of 162 (61.7 ± 13.5 years) patients with COVID-19. We assessed the predictive accuracy of sCys C for COVID-19 severity by the receiver operating characteristic (ROC) curve analysis. The participants were divided into two groups based on the sCys C cut-off value. We evaluated the association between high sCys C level and the development of severe COVID-19 disease, using a COX proportional hazards regression model. The area under the ROC curve was 0.708 (95% CI 0.594-0.822), the cut-off value was 1.245 (mg/L), and the sensitivity and specificity was 79.1% and 60.7%, respectively. A multivariable Cox analysis showed that a higher level of sCys C (adjusted HR 2.78 95% CI 1.25-6.18, p = 0.012) was significantly associated with an increased risk of developing a severe COVID-19 illness. Patients with a higher sCys C level have an increased risk of severe COVID-19 disease. Our findings suggest that early assessing sCys C could help to identify potential severe COVID-19 patients.
探讨血清胱抑素 C（sCys C）在 COVID-19 患者中的潜在预后价值，并确定 sCys C 与严重 COVID-19 疾病的关系。
我们对 162 例（61.7±13.5 岁）COVID-19 患者的病历进行了回顾性分析。我们通过受试者工作特征（ROC）曲线分析评估了 sCys C 对 COVID-19 严重程度的预测准确性。根据 sCys C 截断值将参与者分为两组。我们使用 COX 比例风险回归模型评估了高 sCys C 水平与严重 COVID-19 疾病发生之间的关系。ROC 曲线下面积为 0.708（95%CI 0.594-0.822），截断值为 1.245（mg/L），灵敏度和特异性分别为 79.1%和 60.7%。多变量 Cox 分析表明，较高的 sCys C 水平（调整后的 HR 2.78，95%CI 1.25-6.18，p=0.012）与发生严重 COVID-19 疾病的风险增加显著相关。
sCys C 水平较高的患者发生严重 COVID-19 疾病的风险增加。我们的研究结果表明，早期评估 sCys C 可能有助于识别潜在的严重 COVID-19 患者。
