Bing R F, Booth G C, Heagerty A M, Swales J D
J Hypertens Suppl. 1986 Dec;4(6):S299-302.
Calcium binding to erythrocyte membranes has been determined in patients with essential hypertension (EHT) and normotensive subjects with (NT + FH) and without (NT - FH) a family history of hypertension, to investigate its relationship to high blood pressure. The calcium content of erythrocyte membranes was measured by atomic absorption spectrophotometry after incubation in 0 (basal) or 40 mmol/l (maximal binding) calcium chloride. Basal calcium binding was reduced to a similar extent in both EHT and NT + FH subjects (11.4 +/- 0.5 and 10.9 +/- 0.9 mumol/g protein versus 13.7 +/- 0.6 mumol/g protein in NT - FH, P less than 0.01 for both). Maximal binding showed a similar pattern. These data suggest that cell membrane calcium binding is not directly related to blood pressure elevation but is the result of an inherited cell membrane defect which is present in essential hypertension patients and their relatives and which affects several membrane functions.
为研究钙与高血压的关系，我们测定了原发性高血压（EHT）患者以及有（NT + FH）和无（NT - FH）高血压家族史的血压正常受试者红细胞膜上的钙结合情况。在0（基础）或40 mmol/l（最大结合）氯化钙中孵育后，通过原子吸收分光光度法测量红细胞膜的钙含量。EHT和NT + FH受试者的基础钙结合均降低到相似程度（分别为11.4±0.5和10.9±0.9 μmol/g蛋白，而NT - FH为13.7±0.6 μmol/g蛋白，两者P均小于0.01）。最大结合呈现相似模式。这些数据表明，细胞膜钙结合与血压升高无直接关系，而是一种遗传性细胞膜缺陷的结果，这种缺陷存在于原发性高血压患者及其亲属中，并影响多种膜功能。
