Zhou Yan, Liu Zhenqin, Sun Yuanmei, Zhang Hao, Ruan Jianghai
Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, People's Republic of China.
Department of Neurology, Jianyang People's Hospital, Jianyang, 641400, People's Republic of China.
J Pain Res. 2021 Nov 1;14:3429-3436. doi: 10.2147/JPR.S329068. eCollection 2021.
To investigate whether the brain networks changed in patients with acute peripheral herpes zoster (HZ).
We reviewed the EEG database in Jianyang People's Hospital. Patients with acute HZ (n=71) were enrolled from January 2016 to December 2020. Each included subject underwent a ten-minute and 16-channel EEG examination. Five epochs of 10-second EEG data in resting-state were collected from each HZ patient. Five 10-second resting-state EEG epochs from sex- and age-matched healthy controls (HC, n=71) who reported no history of neurological or psychiatric disorders and visited the hospital for routine physical examinations were collected. Brain network and graph theory analysis based on phase locking value parameter and functional ICA were performed using a self-writing Matlab code and the LORETA KEY tool.
Compared with the HC group, the HZ patients showed significant altered brain networks. The graph theory analysis revealed that the clustering coefficient and local efficiency of full band in HZ patients were lower than those in HC group (<0.05). In beta band, the global efficiency and local efficiency of HZ patients group decreased, compared with healthy group (<0.05). The functional ICA showed that three components showed significant differences between the two groups. In component 2, HZ patients showed excess superior frontal gyrus (BA10) neuro oscillation in delta band and less medial frontal gyrus (BA 11) neuro oscillation in beta and gamma bands than that in HCs. And for component 3, the alpha band of the HZ patients presented increased neuro activities in superior frontal gyrus (BA 11) and decreased neuro activities in occipital lobe (BA 18). In component 4, the inferior frontal gyrus (BA 47) showed excess activity in the left hemisphere and reduced activity in the right hemisphere in delta band, compared with HC group.
Altered brain networks exist in resting-state EEG data of patients with acute HZ. The changes of EEG brain networks in HZ patients are characterized by decreased global efficiency and local efficiency in beta band. Moreover, the spontaneous oscillation of some brain regions involving pain management and the connectivity of default mode network changed in HZ patients. Our study provided novel understanding of HZ from an electrophysiological view, and led to converging evidence for treatment of HZ with neural regulation in future.
探讨急性外周性带状疱疹（HZ）患者的脑网络是否发生改变。
我们回顾了简阳市人民医院的脑电图数据库。纳入2016年1月至2020年12月期间的急性HZ患者（n = 71例）。每位纳入的受试者均接受了10分钟的16导脑电图检查。从每位HZ患者收集5个10秒静息状态的脑电图数据片段。从年龄和性别匹配、无神经或精神疾病史且因常规体检来院就诊的健康对照（HC，n = 71例）中收集5个10秒静息状态的脑电图片段。使用自编的Matlab代码和LORETA KEY工具基于锁相值参数和功能独立成分分析进行脑网络和图论分析。
与HC组相比，HZ患者的脑网络有显著改变。图论分析显示，HZ患者全频段的聚类系数和局部效率低于HC组（<0.05）。在β频段，HZ患者组的全局效率和局部效率较健康组降低（<0.05）。功能独立成分分析显示，两组之间有三个成分存在显著差异。在成分2中，与HC相比，HZ患者在δ频段额上回（BA10）神经振荡增强，在β和γ频段额内侧回（BA11）神经振荡减弱。对于成分3，HZ患者α频段在额上回（BA11）神经活动增强，在枕叶（BA(18)）神经活动减弱。在成分4中，与HC组相比，HZ患者在δ频段左侧额下回（BA47）活动增强，右侧活动减弱。
急性HZ患者静息状态脑电图数据中存在脑网络改变。HZ患者脑电图脑网络的变化特征为β频段全局效率和局部效率降低。此外，HZ患者中一些涉及疼痛管理的脑区自发振荡及默认模式网络的连接性发生了改变。我们的研究从电生理角度为HZ提供了新的认识，并为未来用神经调节治疗HZ提供了越来越多的证据。
