Hu Tulan, Wang Wei, He Chiyi
Department of Gastroenterology, Yijishan Hospital of Wannan Medical College, Wuhu 241000, China.
J Oncol. 2021 Oct 31;2021:1565089. doi: 10.1155/2021/1565089. eCollection 2021.
This study aimed to evaluate the risk factors of developing second primary malignancies (SPMs) among patients with pancreatic neuroendocrine neoplasms (pNENs) and the prognosis of pNENs patients with SPMs (pSPMs) using data from the Surveillance, Epidemiology, and End Results (SEER) database.
Data from patients diagnosed with pNENs between 1988 and 2016 were extracted. A case-control study was conducted to investigate the risk factors of developing SPMs among patients with pNENs. Meanwhile, cox regression analysis was also conducted to obtain the independent prognostic factors in pSPMs.
Of 7,630 patients with pNENs, 326 developed SPMs. Patients with pNENs who had not undergone surgery and had been diagnosed in recent periods had a higher risk of developing SPMs. The following independent prognostic predictors for pSPMs were identified: age, latency period, SEER stage, radiotherapy, and surgery.
These findings may improve the surveillance of risk factors for developing SPMs in patients with pNENs and the prognostic risk factors in pSPMs.
本研究旨在利用监测、流行病学和最终结果（SEER）数据库的数据，评估胰腺神经内分泌肿瘤（pNENs）患者发生第二原发性恶性肿瘤（SPMs）的风险因素以及pNENs合并SPMs（pSPMs）患者的预后情况。
提取1988年至2016年间诊断为pNENs的患者数据。进行病例对照研究以调查pNENs患者发生SPMs的风险因素。同时，进行cox回归分析以获得pSPMs的独立预后因素。
在7630例pNENs患者中，326例发生了SPMs。未接受手术且近期诊断的pNENs患者发生SPMs的风险更高。确定了以下pSPMs的独立预后预测因素：年龄、潜伏期、SEER分期、放疗和手术。
这些发现可能会改善对pNENs患者发生SPMs的风险因素以及pSPMs的预后风险因素的监测。
