Department of Obstetrics, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu, China.
J Healthc Eng. 2021 Oct 31;2021:1709793. doi: 10.1155/2021/1709793. eCollection 2021.
This research was to explore the adoption value of computed tomography (CT) images based on adaptive statistical iterative reconstruction (ASIR) algorithm in the evaluation of probiotics combined with ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy (ICP). A total of 82 patients with ICP were selected as the research subjects and they were randomly rolled into experimental group (380 mg probiotics enteric-soluble capsule twice a day, combined with 90 mg ursodeoxycholic acid soft capsule three times a day) and control group (90 mg ursodeoxycholic acid soft capsule three times a day), with 41 cases in each. The treatment course was four months. The ASIR algorithm was constructed and applied to the CT image analysis and diagnosis of ICP patients. The effects of filtering back projection (FBP) reconstruction and ASIR algorithm on CT image quality, denoising degree, and artifacts of ICP patients were compared. Moreover, blood indicator levels of ICP patients before and after treatment were assessed. The results showed that the SD values of liver and gallbladder (20.77 Hu and 27.58 Hu) in the reconstructed image of the ASIR algorithm were significantly lower than those of the FBP algorithm (40.58 Hu and 45.63 Hu) ( < 0.05). The SNR values of the liver and gallbladder (3.68 and 2.05) of the reconstructed image were significantly higher than those of the FBP algorithm (1.91 and 1.19) ( < 0.05). The overall image quality after ASIR reconstruction (3.92 points) was significantly better than that of the FBP algorithm (2.36 points), and the image noise score (3.21 points) reconstructed by the FBP algorithm was higher than that by the ASIR algorithm (1.83 points). The artifact score of FBP reconstructed image (4.47 points) was greatly higher than that of ASIR algorithm (2.26 points) ( < 0.05). Before treatment, there was no remarkable difference in the indexes between the two groups of patients ( > 0.05). After treatment, the -glutamyltransferase (-GT) and alkaline phosphatase (ALP) levels (327.55 U/L and 778.15 mol/L) of the experimental group of ICP patients were higher than those of the control group (248.63 U/L and 668.43 mol/L), with substantial difference between the two groups ( < 0.05). The blood ammonia (BA) level (151.09 mol/L) of the experimental group was lower than that of the control group (178.46 mol/L), and the difference between the two groups was remarkable ( < 0.05). To sum up, the CT image denoising degree based on ASIR algorithm was high, with few artifacts and good overall quality. Probiotics combined with ursodeoxycholic acid in the treatment of ICP can effectively improve the liver function and intestinal flora of patients, which was of great significance in the clinical diagnosis and treatment of the disease.
本研究旨在探讨基于自适应统计迭代重建（ASIR）算法的 CT 图像在评估益生菌联合熊去氧胆酸治疗妊娠肝内胆汁淤积症（ICP）中的应用价值。选取 82 例 ICP 患者作为研究对象，采用随机数字表法将其分为实验组（380mg 益生菌肠溶胶囊，每日 2 次，联合 90mg 熊去氧胆酸软胶囊，每日 3 次）和对照组（90mg 熊去氧胆酸软胶囊，每日 3 次），每组 41 例。疗程为 4 个月。构建 ASIR 算法并应用于 ICP 患者 CT 图像分析和诊断，比较滤波反投影（FBP）重建和 ASIR 算法对 ICP 患者 CT 图像质量、去噪程度和伪影的影响，评估 ICP 患者治疗前后的血液指标水平。结果显示，ASIR 算法重建图像的肝、胆囊 SD 值（20.77Hu 和 27.58Hu）明显低于 FBP 算法（40.58Hu 和 45.63Hu）（<0.05）。肝、胆囊的 SNR 值（3.68 和 2.05）明显高于 FBP 算法（1.91 和 1.19）（<0.05）。ASIR 重建后整体图像质量（3.92 分）明显优于 FBP 算法（2.36 分），FBP 算法重建图像的噪声评分（3.21 分）高于 ASIR 算法（1.83 分）。FBP 重建图像的伪影评分（4.47 分）明显高于 ASIR 算法（2.26 分）（<0.05）。治疗前，两组患者各指标比较差异均无统计学意义（>0.05）。治疗后，实验组 ICP 患者γ-谷氨酰转肽酶（-GT）和碱性磷酸酶（ALP）水平（327.55U/L 和 778.15μmol/L）高于对照组（248.63U/L 和 668.43μmol/L），差异均有统计学意义（<0.05）。实验组患者血氨（BA）水平（151.09μmol/L）低于对照组（178.46μmol/L），差异有统计学意义（<0.05）。综上所述，基于 ASIR 算法的 CT 图像去噪程度高，伪影少，整体质量好。益生菌联合熊去氧胆酸治疗 ICP 能有效改善患者肝功能和肠道菌群，对疾病的临床诊断和治疗具有重要意义。
