Department of Health Sciences, Federal University of Espírito Santo, São Mateus, Brazil.
Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
J Public Health (Oxf). 2018 Sep 1;40(3):476-484. doi: 10.1093/pubmed/fdx118.
It has been reported that early menarche is associated with high blood pressure and hypertension. However, some studies have failed to observe such association. We carried out a systematic review and meta-analysis on the association of early menarche with hypertension and high blood pressure in adulthood.
PUBMED, SciELO, Scopus and LILACS databases were searched. Studies that evaluated the association of early menarche with hypertension or high blood pressure, among women aged 20 years or more were included. Random effects models were used to pool the estimates. Meta-regression was used to evaluate the contribution of different co-variables to heterogeneity.
We identified 17 studies with 18 estimates on the association of early menarche with hypertension and high blood pressure. The odds of hypertension/high blood pressure was higher among women with early menarche [pooled (OR):1.25; 95% confidence interval (CI): 1.17-1.34; P < 0.001]. In the meta-regression analysis, studies evaluating 1500 subjects or more had a higher pooled OR [1.27; 95%CI (1.19;1.36)] than those with less participants. Although funnel plots showed some asymmetry, Egger tests were not statistically significant. Therefore, it is unlikely that the observed association was to publication bias.
Early menarche is associated with hypertension among adult woman.
已有报道称，初潮较早与高血压和高血压有关。然而，一些研究未能观察到这种关联。我们对初潮较早与成年期高血压和高血压之间的关联进行了系统评价和荟萃分析。
检索了 PUBMED、SciELO、Scopus 和 LILACS 数据库。纳入评估初潮较早与女性 20 岁及以上人群中高血压或高血压之间关联的研究。使用随机效应模型汇总估计值。Meta 回归用于评估不同协变量对异质性的贡献。
我们确定了 17 项研究，其中有 18 项关于初潮较早与高血压和高血压之间关联的评估。初潮较早的女性发生高血压/高血压的几率更高[汇总（OR）：1.25；95%置信区间（CI）：1.17-1.34；P<0.001]。在荟萃回归分析中，评估 1500 名或更多受试者的研究的汇总 OR [1.27；95%CI（1.19；1.36)]高于参与者较少的研究。尽管漏斗图显示出一些不对称，但 Egger 检验没有统计学意义。因此，观察到的关联不太可能是由于发表偏倚所致。
初潮较早与成年女性的高血压有关。
