Department of Internal Medicine, Inje University Haeundae Paik Hospital, Busan, Republic of Korea.
Department of Internal Medicine, Pusan National University Yangsan Hospital, Gyeongnam, Republic of Korea.
Mod Rheumatol. 2022 Oct 15;32(6):1163-1169. doi: 10.1093/mr/roab095.
As the heritability of hyperuricaemia remains largely unexplained, we analysed the association between parental and offspring hyperuricaemia at the phenotype level.
This cross-sectional study included data on 2373 offspring and both-parent pairs from the seventh Korean National Health and Nutrition Examination Survey. Logistic regression and generalised estimating equation analysis were used to evaluate the association between offspring and parental hyperuricaemia adjusting for metabolic risk factors and alcohol intake.
Both maternal and paternal hyperuricaemia were associated with offspring hyperuricaemia among teenagers, but from the age of 20 years, a strong association was observed between offspring and paternal, rather than, maternal hyperuricaemia, and this could not be explained by metabolic risk factors such as obesity. However, there was a positive interaction between offspring alcohol intake and parental hyperuricaemia, and there was a stronger association between terciles of offspring alcohol intake and hyperuricaemia in the presence of parental hyperuricaemia: T1 (reference), T2 odds ratio (OR) 1.1 (0.3-4.6), and T3 OR 3.3 (1.4-7.9) (P for trend .017) vs. T1 (reference), T2 OR 0.7 (0.3-1.9), and T3 OR 1.1 (0.6-2.2) (P for trend .974).
These results suggest a gene-environment interaction, especially with respect to alcohol intake for hyperuricaemia in Korean adults.
由于高尿酸血症的遗传率仍未得到充分解释，我们分析了表型水平父母与子女高尿酸血症之间的关联。
本横断面研究纳入了第七次韩国国家健康与营养调查中的 2373 名子女及其双亲对子数据。使用逻辑回归和广义估计方程分析，调整代谢危险因素和酒精摄入量，评估子女与父母高尿酸血症之间的关联。
母亲和父亲的高尿酸血症均与青少年子女的高尿酸血症相关，但从 20 岁开始，子女与父亲的高尿酸血症之间存在强烈关联，而与母亲的高尿酸血症关联较弱，这种关联不能用肥胖等代谢危险因素来解释。然而，子女的酒精摄入量与父母的高尿酸血症之间存在正交互作用，在父母存在高尿酸血症的情况下，子女酒精摄入量的三分位数与高尿酸血症之间的关联更强：T1（参考），T2 比值比（OR）1.1（0.3-4.6），T3 OR 3.3（1.4-7.9）（P 趋势.017）vs. T1（参考），T2 OR 0.7（0.3-1.9），T3 OR 1.1（0.6-2.2）（P 趋势.974）。
这些结果表明存在基因-环境相互作用，特别是在韩国成年人高尿酸血症与酒精摄入之间。
