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一项用于预防儿童哮喘持续状态住院治疗的皮质类固醇方案。

A corticosteroid program for prevention of hospitalization for status asthmaticus in children.

作者信息

Resnick A, Greenberger P A

出版信息

N Engl Reg Allergy Proc. 1987 Mar-Apr;8(2):104-7. doi: 10.2500/108854187778994419.

Abstract

This study assessed the efficacy of an outpatient course of prednisone in the treatment of acute asthma, as a method of preventing hospitalization for status asthmaticus. From September-November 1984, 181 courses of prednisone were utilized by children for acute exacerbations of asthma inadequately controlled by bronchodilators and inhaled beclomethasone dipropionate or cromolyn. The dose of prednisone was 1 mg/kg/day for five days with a maximum of 40 mg/day. Only ten children required hospitalization for status asthmaticus. Privately insured patients and non-privately insured patients accounted for 61 and 120 of the prednisone courses, respectively, of which five children from each group required hospitalization. The data suggest that short-term administration of prednisone for exacerbations of asthma was valuable in decreasing the need for hospitalization for asthma among bronchodilator-treated asthmatics. Further, patients from families without private hospitalization insurance appear as amenable to prednisone-intervention as privately insured patients.

摘要

本研究评估了门诊使用泼尼松治疗急性哮喘的疗效,作为预防哮喘持续状态住院的一种方法。1984年9月至11月,181例儿童使用泼尼松治疗哮喘急性加重,这些患儿的哮喘发作经支气管扩张剂、吸入丙酸倍氯米松或色甘酸钠治疗后控制不佳。泼尼松剂量为1mg/kg/天,连用5天,最大剂量为40mg/天。只有10名儿童因哮喘持续状态需要住院治疗。参加私人保险的患者和未参加私人保险的患者分别使用了61例和120例泼尼松疗程,每组各有5名儿童需要住院治疗。数据表明,对哮喘加重期短期使用泼尼松对减少支气管扩张剂治疗的哮喘患者因哮喘住院的需求有价值。此外,没有私人住院保险家庭的患者似乎与参加私人保险的患者一样适合接受泼尼松干预。

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