Toogood J H
N Engl Reg Allergy Proc. 1987 Mar-Apr;8(2):98-103. doi: 10.2500/108854187778994464.
The therapeutic efficiency of oral vs. inhaled steroid treatment for chronic asthma was compared in several graded-dose, double-blind controlled trials. Inhaled steroid proved significantly more effective than alternate-morning prednisone when the two regimens were compared in the same patients at equivalent levels of systemic glucocorticoid activity. Furthermore, if given in sufficient dosage, inhaled steroids proved equally as effective as oral prednisone given daily, and better tolerated than the latter. The data support a broadening of the therapeutic role of inhaled steroid drugs to include higher dosages and patients with more severe grades of asthma. To facilitate this, concentrated formulations are needed. Until the latter become available to the practitioner, combinations of inhaled plus oral steroid treatment may be used, since these have been shown to improve the efficacy of chronic steroid therapy without worsening its adverse effects.
在多项分级剂量、双盲对照试验中，对口服与吸入类固醇治疗慢性哮喘的疗效进行了比较。当在相同患者中以等效的全身糖皮质激素活性水平比较两种治疗方案时，吸入类固醇被证明比隔日早晨服用泼尼松显著更有效。此外，如果给予足够的剂量，吸入类固醇被证明与每日口服泼尼松同样有效，并且耐受性比后者更好。这些数据支持扩大吸入类固醇药物的治疗作用，以包括更高剂量和更严重等级哮喘的患者。为便于实现这一点，需要浓缩制剂。在从业者能够获得后者之前，可以使用吸入加口服类固醇治疗的联合方案，因为这些已被证明可提高慢性类固醇治疗的疗效而不会使其不良反应恶化。
