Doostmohammadi Amin, Ladoux Benoit
The Niels Bohr Institute, University of Copenhagen, Copenhagen, Denmark.
Institut Jacques-Monod, Université de Paris & CNRS UMR 7592, Paris, France.
Trends Cell Biol. 2022 Feb;32(2):140-150. doi: 10.1016/j.tcb.2021.09.012. Epub 2021 Oct 27.
The past decade has witnessed a rapid growth in understanding of the pivotal roles of mechanical stresses and physical forces in cell biology. As a result, an integrated view of cell biology is evolving, where genetic and molecular features are scrutinised hand in hand with physical and mechanical characteristics of cells. Physics of liquid crystals has emerged as a burgeoning new frontier in cell biology over the past few years, fuelled by an increasing identification of orientational order and topological defects in cell biology, spanning scales from subcellular filaments to individual cells and multicellular tissues. Here, we provide an account of the most recent findings and developments, together with future promises and challenges in this rapidly evolving interdisciplinary research direction.
在过去十年中，人们对机械应力和物理力在细胞生物学中的关键作用的理解迅速增长。因此，细胞生物学的综合观点正在形成，其中遗传和分子特征与细胞的物理和机械特征一起受到审视。在过去几年中，液晶物理学已成为细胞生物学中一个新兴的前沿领域，这得益于细胞生物学中从亚细胞细丝到单个细胞和多细胞组织等尺度上取向有序和拓扑缺陷的不断发现。在此，我们介绍了这一快速发展的跨学科研究方向的最新发现和进展，以及未来的前景和挑战。
