Anderson E C, Williams S M, Fisher-Hoch S P, Wilkinson P J
Res Vet Sci. 1987 May;42(3):387-94.
Changes in the production of proaggregatory (thromboxane A2 and prostaglandin E2) and antiaggregatory (prostacyclin) prostaglandins by blood platelets, macrophages and endothelial cells during acute African swine fever caused by both a highly virulent virus and a less virulent virus were studied. No impairment in thromboxane A2 release by either platelets or macrophages could be detected but prostacyclin production by the endothelium was impaired. There was also a significant increase in prostaglandin E2 release by macrophages at the time when thrombocytopenia was most marked. However, the early event that causes primary aggregation remains obscure.
研究了高毒力病毒和低毒力病毒引起的急性非洲猪瘟期间，血小板、巨噬细胞和内皮细胞产生促聚集性前列腺素（血栓素A2和前列腺素E2）和抗聚集性前列腺素（前列环素）的变化。未检测到血小板或巨噬细胞释放血栓素A2有受损情况，但内皮细胞产生前列环素受到了损害。在血小板减少最为明显时，巨噬细胞释放前列腺素E2也显著增加。然而，导致初始聚集的早期事件仍不清楚。
