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遗传预测血压盐敏感性:同一生物途径中的 2 个命中的累加影响。

Genetic Predictors of Salt Sensitivity of Blood Pressure: The Additive Impact of 2 Hits in the Same Biological Pathway.

机构信息

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (A.V.H., Y.E.Y., J.S.W., G.K.A., G.H.W.).

Cell and Molecular Biology Laboratory, Department of Cellular Biology and Pharmacology, Faculty of Medicine and Health Sciences, UCSI University, Cheras, Kuala Lumpur, Malaysia (L.E.Y., Y.H.W.).

出版信息

Hypertension. 2021 Dec;78(6):1809-1817. doi: 10.1161/HYPERTENSIONAHA.121.18033. Epub 2021 Nov 10.

DOI:10.1161/HYPERTENSIONAHA.121.18033
PMID:34757767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8589116/
Abstract

[Figure: see text].

摘要

[图:见正文]。

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Steroids. 2019 Dec;152:108486. doi: 10.1016/j.steroids.2019.108486. Epub 2019 Sep 6.
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High Salt Activates CD11c Antigen-Presenting Cells via SGK (Serum Glucocorticoid Kinase) 1 to Promote Renal Inflammation and Salt-Sensitive Hypertension.高盐通过 SGK1(血清糖皮质激素激酶 1)激活 CD11c 抗原呈递细胞,促进肾脏炎症和盐敏感性高血压。
Hypertension. 2019 Sep;74(3):555-563. doi: 10.1161/HYPERTENSIONAHA.119.12761. Epub 2019 Jul 8.
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Genetics of Human Primary Hypertension: Focus on Hormonal Mechanisms.原发性高血压的遗传学研究:聚焦于激素机制。
Endocr Rev. 2019 Jun 1;40(3):825-856. doi: 10.1210/er.2018-00071.
5
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J Clin Endocrinol Metab. 2017 Nov 1;102(11):4124-4135. doi: 10.1210/jc.2017-00957.
6
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Hypertension. 2016 Sep;68(3):e7-e46. doi: 10.1161/HYP.0000000000000047. Epub 2016 Jul 21.
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