Han Dae-Hee, Lee Shin Hyung, Seo Dong-Chul
Department of Applied Health Science, Indiana University School of Public Health, Bloomington, IN, USA.
Nicotine Tob Res. 2022 Mar 1;24(4):590-597. doi: 10.1093/ntr/ntab232.
Prior studies that examined the role of electronic nicotine delivery systems (ENDS) use in smoking cessation have shown divergent conclusions. This study examined the time-course of ENDS-associated smoking abstinent behaviors among continuing cigarette smokers who were willing but unable to quit smoking.
Data were drawn from the four waves of the Population Assessment of Tobacco and Health Study. Of the 1684 smokers who tried to quit smoking completely at Wave 1, a total of 1094 who were continuing smokers until Wave 4 and were not lost to follow-ups comprised the sample. Using generalized linear mixed modeling, we fitted weighted negative binomial regression models to examine within-person associations of ENDS use with quit attempts and number of days abstinent from smoking.
Quit attempt frequency and smoking abstinent days were highest at Wave 1, dropped at Wave 2, and then either increased a little or remained stagnant in later waves. ENDS use to quit smoking was associated with more frequent quit attempts (aIRR = 1.67, 95% CI = 1.42-1.95) and more abstinent days (aIRR = 3.28, 95% CI = 2.43-4.44), and the magnitude of such associations became stronger over time. ENDS use was associated with becoming a nondaily smoker among baseline daily smokers.
ENDS use among continuing smokers may help increase the number of quit attempts and smoking abstinent days. Given that the study sample is continuing smokers who failed in complete smoking cessation, future research would be desirable that evaluates whether such abstinent behaviors sustain and manifest harm reduction with improved health outcomes.
Smokers increasingly adopt electronic nicotine delivery systems (ENDS) to quit smoking. However, the association of ENDS use with smoking cessation efforts among continuing cigarette smokers who were willing but unable to quit smoking is largely unknown. This study found that quit attempts and smoking abstinent days increased with ENDS use to quit smoking by following up with population-representative continuing smokers. Additionally, this study assessed whether cigarette smokers' abstinent behaviors vary with their use of ENDS by estimating within-person associations with frequent assessments of both exposures and outcomes in a long-term perspective.
先前研究电子尼古丁传送系统（ENDS）在戒烟中作用的研究得出了不同结论。本研究调查了有戒烟意愿但无法戒烟的持续吸烟者中与ENDS相关的戒烟行为的时间进程。
数据取自烟草与健康人口评估研究的四个阶段。在第1阶段试图完全戒烟的1684名吸烟者中，共有1094名持续吸烟者直至第4阶段且未失访，构成了样本。使用广义线性混合模型，我们拟合了加权负二项回归模型，以检验个体内部ENDS使用与戒烟尝试以及戒烟天数之间的关联。
戒烟尝试频率和戒烟天数在第1阶段最高，在第2阶段下降，然后在后续阶段略有增加或保持停滞。使用ENDS戒烟与更频繁的戒烟尝试（调整后发病率比[aIRR]=1.67，95%置信区间[CI]=1.42 - 1.95）和更多的戒烟天数（aIRR = 3.28，95% CI = 2.43 - 4.44）相关，且这种关联的强度随时间增强。在基线时每日吸烟的人群中，使用ENDS与成为非每日吸烟者相关。
持续吸烟者使用ENDS可能有助于增加戒烟尝试次数和戒烟天数。鉴于本研究样本是完全戒烟失败的持续吸烟者，未来需要进行研究来评估这种戒烟行为是否持续以及是否能实现危害降低并改善健康结果。
吸烟者越来越多地采用电子尼古丁传送系统（ENDS）来戒烟。然而，在有戒烟意愿但无法戒烟的持续吸烟者中，ENDS使用与戒烟努力之间的关联在很大程度上尚不清楚。本研究通过对具有人群代表性的持续吸烟者进行随访发现，使用ENDS戒烟会增加戒烟尝试次数和戒烟天数。此外，本研究通过从长期角度估计个体内部暴露和结果的频繁评估之间的关联，评估了吸烟者的戒烟行为是否因ENDS使用而有所不同。
