School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Nat Prod Res. 2023 Apr;37(8):1300-1309. doi: 10.1080/14786419.2021.2003796. Epub 2021 Nov 10.
Euphorfinoids A and B ( and ), a pair of -atisane diterpenoid epimers with a vicinal 2,3-diol moiety, together with four known analogues (), were isolated from the roots of wild . Their structures were elucidated by spectroscopic analysis, including extensive NMR, HR-ESIMS, NMR calculations, X-ray diffraction, and comparison with structurally related known analogues. Our bioassays have established that compound displayed moderate anti-proliferative effects on Hcc1806 cell line with IC 15.53 ± 0.21 μM, and compound showed remarkable inhibitory effects against AChE with IC 32.56 ± 2.74 μM by an screened experiment.
Euphorfinoids A 和 B（和），一对具有相邻 2,3-二醇部分的 -atisane 二萜类差向异构体，以及四个已知类似物（），从野生的根部分离得到。通过包括广泛的 NMR、HR-ESIMS、NMR 计算、X 射线衍射和与结构相关的已知类似物比较在内的光谱分析，阐明了它们的结构。我们的生物测定已经确定，化合物在 Hcc1806 细胞系中表现出中等的抗增殖作用，IC 为 15.53 ± 0.21 μM，而化合物通过筛选实验对 AChE 表现出显著的抑制作用，IC 为 32.56 ± 2.74 μM。
