Wang Liang, Zhu Jian, Maehara Akiko, Lv Rui, Qu Yangyang, Zhang Xiaoguo, Guo Xiaoya, Billiar Kristen L, Chen Lijuan, Ma Genshan, Mintz Gary S, Tang Dalin
School of Biological Science and Medical Engineering, Southeast University, Nanjing, China.
Department of Cardiology, Zhongda Hospital, Southeast University, Nanjing, China.
Front Physiol. 2021 Oct 25;12:721195. doi: 10.3389/fphys.2021.721195. eCollection 2021.
Mechanical forces are closely associated with plaque progression and rupture. Precise quantifications of biomechanical conditions using image-based computational models depend heavily on the accurate estimation of patient-specific plaque mechanical properties. Currently, mechanical experiments are commonly performed on cardiovascular tissues to determine plaque material properties. Patient-specific coronary material properties are scarce in the existing literature. Cine intravascular ultrasound and virtual histology intravascular ultrasound (IVUS) slices were acquired at 20 plaque sites from 13 patients. A three-dimensional thin-slice structure-only model was constructed for each slice to obtain patient-specific material parameter values following an iterative scheme. Effective Young's modulus (YM) was calculated to indicate plaque stiffness for easy comparison purposes. IVUS-based 3D thin-slice models using and material properties were constructed to investigate their impacts on plaque wall stress/strain (PWS/PWSn) calculations. The average YM values in the axial and circumferential directions for the 20 plaque slices were 599.5 and 1,042.8 kPa, respectively, 36.1% lower than those from published data. The YM values in the circumferential direction of the softest and stiffest plaques were 103.4 and 2,317.3 kPa, respectively. The relative difference of mean PWSn on lumen using the and material properties could be as high as 431%, while the relative difference of mean PWS was much lower, about 3.07% on average. There is a large inter-patient and intra-patient variability in the plaque material properties. material properties have a great impact on plaque stress/strain calculations. plaque material properties have a greater impact on strain calculations. Large-scale-patient studies are needed to further verify our findings.
机械力与斑块进展和破裂密切相关。使用基于图像的计算模型对生物力学条件进行精确量化在很大程度上依赖于对患者特异性斑块力学特性的准确估计。目前，通常在心血管组织上进行力学实验以确定斑块材料特性。现有文献中缺乏患者特异性冠状动脉材料特性。从13名患者的20个斑块部位获取了血管内超声电影和虚拟组织学血管内超声（IVUS）切片。为每个切片构建了三维仅薄片结构模型，以通过迭代方案获得患者特异性材料参数值。计算有效杨氏模量（YM）以指示斑块硬度，便于进行比较。构建了使用不同材料特性的基于IVUS的三维薄片模型，以研究它们对斑块壁应力/应变（PWS/PWSn）计算的影响。20个斑块切片在轴向和周向的平均YM值分别为599.5和1042.8 kPa，比已发表数据低36.1%。最软和最硬斑块在周向的YM值分别为103.4和2317.3 kPa。使用不同材料特性时，管腔平均PWSn的相对差异可能高达431%，而平均PWS的相对差异要低得多，平均约为3.07%。斑块材料特性在患者间和患者内存在很大差异。材料特性对斑块应力/应变计算有很大影响。斑块材料特性对应变计算的影响更大。需要进行大规模患者研究以进一步验证我们的发现。
