Huang Xueying, Yang Chun, Zheng Jie, Bach Richard, Muccigrosso David, Woodard Pamela K, Tang Dalin
School of Mathematical Sciences, Xiamen University, Xiamen, Fujian 361005, China; Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computation, Xiamen University, Xiamen, Fujian 361005 China; Department of Mathematical Sciences, Worcester Polytechnic Institute, MA 01609, USA.
Department of Mathematical Sciences, Worcester Polytechnic Institute, MA 01609, USA; Network Technology Research Institute, China United Network Communications Co., Ltd., Beijing, China.
J Biomech. 2016 Sep 6;49(13):2726-2733. doi: 10.1016/j.jbiomech.2016.06.002. Epub 2016 Jun 8.
MRI-based fluid-structure interactions (FSI) models for atherosclerotic plaques have been developed to perform mechanical analysis to investigate the association of plaque wall stress (PWS) with cardiovascular disease. However, the time consuming 3D FSI model construction process is a great hinder for its clinical implementations. In this study, a 3D thin-layer structure only (TLS) plaque model was proposed as an approximation with much less computational cost to 3D FSI models for better clinical implementation potential. 192 TLS models were constructed based on 192 ex vivo MRI Images of 12 human coronary atherosclerotic plaques. Plaque stresses were extracted from all lumen nodal points. The maximum value of Plaque wall stress (MPWS) and average value of plaque wall stress (APWS) of each slice were used to compare with those from corresponding FSI models. The relative errors for MPWS and APWS were 9.76% and 9.89%, respectively. Both MPWS and APWS values obtained from TLS models showed very good correlation with those from 3D FSI models. Correlation results from TLS models were in consistent with FSI models. Our results indicated that the proposed 3D TLS plaque models may be used as a good approximation to 3D FSI models with much less computational cost. With further validation, 3D TLS models may be possibly used to replace FSI models to save time and perform mechanical analysis for atherosclerotic plaques for clinical implementation.
基于磁共振成像（MRI）的动脉粥样硬化斑块流固耦合（FSI）模型已被开发出来，用于进行力学分析，以研究斑块壁应力（PWS）与心血管疾病之间的关联。然而，耗时的三维FSI模型构建过程极大地阻碍了其临床应用。在本研究中，提出了一种仅包含三维薄层结构（TLS）的斑块模型，作为三维FSI模型的近似模型，其计算成本要低得多，具有更好的临床应用潜力。基于12个人类冠状动脉粥样硬化斑块的192张离体MRI图像构建了192个TLS模型。从所有管腔节点提取斑块应力。使用每个切片的斑块壁应力最大值（MPWS）和斑块壁应力平均值（APWS）与相应FSI模型的结果进行比较。MPWS和APWS的相对误差分别为9.76%和9.89%。从TLS模型获得的MPWS和APWS值与三维FSI模型的值均显示出非常好的相关性。TLS模型的相关性结果与FSI模型一致。我们的结果表明，所提出的三维TLS斑块模型可以作为三维FSI模型的良好近似，且计算成本要低得多。经过进一步验证，三维TLS模型可能会用于取代FSI模型，以节省时间并对动脉粥样硬化斑块进行力学分析，用于临床应用。
