在伊朗人群中运用因果方法研究吸烟对代谢综合征及其组分的影响
The Effects of Smoking on Metabolic Syndrome and Its Components Using Causal Methods in the Iranian Population.
作者信息
Khodamoradi Farzad, Nazemipour Maryam, Mansournia Nasrin, Yazdani Kamran, Khalili Davood, Mansournia Mohammad Ali
机构信息
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Int J Prev Med. 2021 Sep 29;12:118. doi: 10.4103/ijpvm.ijpvm_45_21. eCollection 2021.
BACKGROUND
The aim of this study was to estimate the effect of smoking on metabolic syndrome (MS) and its components applying inverse probability-of-treatment weighting (IPTW) and propensity score (PS) matching.
METHODS
Using data from Tehran Lipid and Glucose Study, 4857 participants aged over 20 years with information on smoking and confounders in the third phase (2005-2008) were included, and the MS was assessed in the fifth phase (2011-2014). IPTW and PS matching were used to adjust for confounders.
RESULTS
Based on average treatment effect (ATE) estimates, smoking decreased the risk of hypertension (RR: 0.62; 95% CI: 0.43, 0.88), but increased the risk of low HDL cholesterol (1.20; 0.98, 1.48). Similarly, the average treatment effect in the treated (ATT) estimates using IPTW and PS matching suggested that smoking decreased the risk of hypertension (0.63; 0.52, 0.76, and 0.68; 0.54, 0.85), and increased the risk of low HDL cholesterol (1.24; 1.07, 1.43, and 1.28; 1.06, 1.54), respectively.
CONCLUSIONS
Smoking seems to increase the risk of low HDL cholesterol but decreases the risk of hypertension.
背景
本研究旨在运用逆概率处理加权法（IPTW）和倾向得分（PS）匹配法评估吸烟对代谢综合征（MS）及其组分的影响。
方法
采用德黑兰血脂与血糖研究的数据，纳入4857名20岁以上在第三阶段（2005 - 2008年）有吸烟及混杂因素信息的参与者，并在第五阶段（2011 - 2014年）评估MS。使用IPTW和PS匹配法调整混杂因素。
结果
基于平均治疗效应（ATE）估计，吸烟降低了高血压风险（风险比：0.62；95%置信区间：0.43，0.88），但增加了低高密度脂蛋白胆固醇风险（1.20；0.98，1.48）。同样，使用IPTW和PS匹配法的处理组平均治疗效应（ATT）估计表明，吸烟分别降低了高血压风险（0.63；0.52，0.76和0.68；0.54，0.85），并增加了低高密度脂蛋白胆固醇风险（1.24；1.07，1.43和1.28；1.06，1.54）。
结论
吸烟似乎增加了低高密度脂蛋白胆固醇风险，但降低了高血压风险。
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