Savvidou Olga, Papakonstantinou Olympia, Lakiotaki Eleftheria, Zafeiris Ioannis, Melissaridou Dimitra, Korkolopoulou Pinelopi, Papagelopoulos Panayiotis J
First Department of Orthopaedic Surgery, National and Kapodistrian University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece.
These authors contributed equally to this manuscript.
EFORT Open Rev. 2021 Oct 19;6(10):905-917. doi: 10.1302/2058-5241.6.210064. eCollection 2021 Oct.
Surface bone sarcomas are rare malignant bone tumours. Osseous and cartilaginous surface bone sarcomas are the most common, with parosteal and periosteal osteosarcomas, periosteal chondrosarcomas and secondary peripheral chondrosarcomas being the most frequent.Their clinical symptoms are non-specific and include pain for several months, swelling and limited range of motion of the adjacent joints.Prompt diagnosis is important, as biological behaviour, imaging and histopathologic characteristics, treatment and prognosis differ considerably from their conventional intramedullary counterparts. Moreover, their imaging characteristics are not infrequently non-characteristic and may be misinterpreted as juxtacortical benign lesions leading to incorrect diagnosis and treatment, with life-threatening repercussions. Molecular studies and histopathological sampling are essential for accurate diagnosis.There are still numerous issues regarding the biology, pathophysiology and treatment options of these entities due to their rarity. Cite this article: 2021;6:905-917. DOI: 10.1302/2058-5241.6.210064.
骨表面肉瘤是罕见的恶性骨肿瘤。骨源性和软骨性骨表面肉瘤最为常见，其中骨旁骨肉瘤、骨膜骨肉瘤、骨膜软骨肉瘤和继发性外周软骨肉瘤最为频发。其临床症状不具特异性，包括数月的疼痛、肿胀以及相邻关节活动受限。及时诊断很重要，因为其生物学行为、影像学和组织病理学特征、治疗及预后与传统的髓内同类肿瘤有很大差异。此外，它们的影像学特征常常不典型，可能被误诊为皮质旁良性病变，从而导致错误的诊断和治疗，产生危及生命的后果。分子研究和组织病理学采样对于准确诊断至关重要。由于这些实体肿瘤罕见，关于其生物学、病理生理学和治疗选择仍存在许多问题。引用本文：2021;6:905 - 917。DOI: 10.1302/2058 - 5241.6.210064。
