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评估三种市售剂量仪检测静态调强放疗计划中系统输送误差的能力。

Evaluation of the ability of three commercially available dosimeters to detect systematic delivery errors in step-and-shoot IMRT plans.

作者信息

Gray Alison, Bawazeer Omemh, Arumugam Sankar, Vial Philip, Descallar Joseph, Thwaites David, Holloway Lois

机构信息

Liverpool and Macarthur Cancer Therapy Centres, South Western Sydney Local Health District, Sydney, NSW, Australia.

Ingham Institute for Applied Medical Research, Sydney, NSW, Australia.

出版信息

Rep Pract Oncol Radiother. 2021 Sep 30;26(5):793-803. doi: 10.5603/RPOR.a2021.0093. eCollection 2021.

Abstract

BACKGROUND

There is limited data on error detectability for step-and-shoot intensity modulated radiotherapy (sIMRT) plans, despite significant work on dynamic methods. However, sIMRT treatments have an ongoing role in clinical practice. This study aimed to evaluate variations in the sensitivity of three patient-specific quality assurance (QA) devices to systematic delivery errors in sIMRT plans.

MATERIALS AND METHODS

Four clinical sIMRT plans (prostate and head and neck) were edited to introduce errors in: Multi-Leaf Collimator (MLC) position (increasing field size, leaf pairs offset (1-3 mm) in opposite directions; and field shift, all leaves offset (1-3 mm) in one direction); collimator rotation (1-3 degrees) and gantry rotation (0.5-2 degrees). The total dose for each plan was measured using an ArcCHECK diode array. Each field, excluding those with gantry offsets, was also measured using an Electronic Portal Imager and a MatriXX Evolution 2D ionisation chamber array. 132 plans (858 fields) were delivered, producing 572 measured dose distributions. Measured doses were compared to calculated doses for the no-error plan using Gamma analysis with 3%/3 mm, 3%/2 mm, and 2%/2 mm criteria (1716 analyses).

RESULTS

Generally, pass rates decreased with increasing errors and/or stricter gamma criteria. Pass rate variations with detector and plan type were also observed. For a 3%/3 mm gamma criteria, none of the devices could reliably detect 1 mm MLC position errors or 1 degree collimator rotation errors.

CONCLUSIONS

This work has highlighted the need to adapt QA based on treatment plan type and the need for detector specific assessment criteria to detect clinically significant errors.

摘要

背景

尽管在动态调强放疗方法方面开展了大量工作,但关于步进式调强放疗(sIMRT)计划的误差可检测性的数据有限。然而,sIMRT治疗在临床实践中仍发挥着持续作用。本研究旨在评估三种针对患者的质量保证(QA)设备对sIMRT计划中系统输送误差的敏感性差异。

材料与方法

对四个临床sIMRT计划(前列腺和头颈部)进行编辑,以引入以下方面的误差:多叶准直器(MLC)位置(增加射野大小,叶片对在相反方向偏移(1 - 3毫米);以及射野移位,所有叶片在一个方向偏移(1 - 3毫米));准直器旋转(1 - 3度)和机架旋转(0.5 - 2度)。使用ArcCHECK二极管阵列测量每个计划的总剂量。除了那些有机架偏移的射野外,每个射野还使用电子射野成像器和MatriXX Evolution二维电离室阵列进行测量。共输送了132个计划(858个射野),产生了572个测量剂量分布。使用3%/3毫米、3%/2毫米和2%/2毫米标准的伽马分析,将测量剂量与无误差计划的计算剂量进行比较(1716次分析)。

结果

一般来说,通过率随着误差增加和/或伽马标准更严格而降低。还观察到通过率随探测器和计划类型的变化。对于3%/3毫米的伽马标准,没有一个设备能够可靠地检测到1毫米的MLC位置误差或1度的准直器旋转误差。

结论

这项工作强调了根据治疗计划类型调整QA的必要性,以及需要针对探测器制定特定的评估标准以检测具有临床意义的误差。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e277/8575358/f84f04f362f1/rpor-26-5-793f1.jpg

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