Zhou Jun, Zhao Zhengyu, Shibata Norio
Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Nagoya, Japan.
Institute of Advanced Fluorine-Containing Materials, Zhejiang Normal University, Jinhua, China.
Front Chem. 2021 Oct 25;9:771473. doi: 10.3389/fchem.2021.771473. eCollection 2021.
The defluorosilylation of aryl fluorides to access aryl silanes was achieved under transition-metal-free conditions an inert C-F bond activation. The defluorosilylation, mediated by silylboronates and KOtBu, proceeded smoothly at room temperature to afford various aryl silanes in good yields. Although a comparative experiment indicated that Ni catalyst facilitated this transformation more efficiently, the transition-metal-free protocol is advantageous from a green chemistry perspective.
在无过渡金属条件下，通过惰性C-F键活化实现了芳基氟化物向芳基硅烷的脱氟硅基化反应。由硼酸硅酯和叔丁醇钾介导的脱氟硅基化反应在室温下顺利进行，以良好的产率得到了各种芳基硅烷。尽管对比实验表明镍催化剂能更有效地促进这种转化，但从绿色化学的角度来看，无过渡金属的方案具有优势。
