Department of Internal Medicine III, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Department of Internal Medicine I, University Medical Center of the Johannes Gutenberg-University, Langenbeckstrasse 1, 55131, Mainz, Germany.
Support Care Cancer. 2022 Mar;30(3):2387-2395. doi: 10.1007/s00520-021-06677-w. Epub 2021 Nov 10.
The aim of this study was to explore the incidence of depression and anxiety disorder diagnoses in a large German cohort of patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) diagnoses in comparison to patients without cancer over a 10-year time frame.
Patients with HL (n=687) and NHL (n=4130) were matched to cohorts without a cancer diagnosis (n=687 and 4130) by age, sex, and yearly consultation frequency. The primary outcome of the study was the incidence of depression and anxiety disorders. The relationship between lymphoma, separated into HL and NHL, and both depression and anxiety disorders was investigated using Cox regression models.
We compared 687 patients with HL with 687 matched non-cancer individuals and 4130 patients with NHL with 4130 matched non-cancer individuals. Within 10 years of the index date, 24.0% of patients with HL and 22.3% of patients with NHL were diagnosed with depression. Anxiety disorders were diagnosed in 6.7% and 5.3% of patients with HL and NHL, respectively. On regression analyses, HL (HR 2.30, 95% CI 1.65-3.21, p<0.001) and NHL (HR 2.09, 95% CI 1.81-2.41, p<0.001) were positively associated with incident depression. The HR for anxiety disorders was 1.64 (95% CI 1.24-2.16, p<0.001) in patients with NHL, while HL was not associated with incident anxiety disorders (HR 1.21, 95% CI 0.71-2.07, p<0.478).
Lymphoma constitutes a risk factor for emerging depression and anxiety disorders. Following the diagnosis of lymphoma, screening and strategies to prevent the occurrence of these diseases seem warranted.
本研究旨在探讨在 10 年时间内，与无癌症患者相比，大量德国霍奇金淋巴瘤 (HL) 和非霍奇金淋巴瘤 (NHL) 患者的抑郁和焦虑障碍诊断的发生率。
通过年龄、性别和每年就诊频率，将 687 例 HL 患者和 4130 例 NHL 患者与无癌症诊断的队列 (687 例和 4130 例) 相匹配。该研究的主要结局是抑郁和焦虑障碍的发生率。使用 Cox 回归模型研究淋巴瘤（分为 HL 和 NHL）与抑郁和焦虑障碍之间的关系。
我们比较了 687 例 HL 患者与 687 例匹配的非癌症个体，以及 4130 例 NHL 患者与 4130 例匹配的非癌症个体。在索引日期后的 10 年内，24.0%的 HL 患者和 22.3%的 NHL 患者被诊断患有抑郁症。分别有 6.7%和 5.3%的 HL 和 NHL 患者被诊断为焦虑症。在回归分析中，HL（HR 2.30，95%CI 1.65-3.21，p<0.001）和 NHL（HR 2.09，95%CI 1.81-2.41，p<0.001）与新发抑郁症呈正相关。NHL 患者新发焦虑症的 HR 为 1.64（95%CI 1.24-2.16，p<0.001），而 HL 与新发焦虑症无关（HR 1.21，95%CI 0.71-2.07，p<0.478）。
淋巴瘤是新发抑郁和焦虑障碍的危险因素。在诊断为淋巴瘤后，筛查和预防这些疾病发生的策略似乎是合理的。
