School of Medicine and Psychology, College of Health and Medicine, Australian National University, Canberra, Australia.
Cancer Med. 2023 Jul;12(13):14646-14662. doi: 10.1002/cam4.6069. Epub 2023 May 17.
Distress is prevalent among lymphoma patients/survivors. Current processes of distress identification rely on self-reporting by patients/survivors, which may be limited by their willingness to report symptoms. To help identify patients/survivors at greater risk, this systematic review aims to comprehensively review factors that may contribute to distress in lymphoma patients/survivors.
PubMed was systematically searched for peer-reviewed primary articles (1997-2022) consisting of standardised keywords "lymphoma" and "distress." Information from 41 articles was integrated via narrative synthesis.
Consistent risk factors of distress include younger age, relapsed disease, and greater comorbidities and symptom burden. Active treatment and the transition from treatment to post-treatment could be challenging phases. Adequate social support, adaptive adjustment to cancer, engaging in work and healthcare professionals' support may mitigate distress. There is some evidence that older age may be associated with greater depression and life changes/experiences may shape how individuals cope with lymphoma. Gender and marital status were not robust predictors of distress. Other clinical, psychological and socioeconomic factors are understudied or have mixed findings.
While several factors of distress align with that of other cancers, more research is needed to identify significant factors of distress in lymphoma patients/survivors. The identified factors may support clinicians in identifying distressed lymphoma patients/survivors and providing interventions where necessary. The review also highlights avenues for future research and a need to routinely collect data on distress and its factors in registries.
淋巴瘤患者/幸存者普遍存在痛苦。目前的痛苦识别过程依赖于患者/幸存者的自我报告，这可能受到他们报告症状的意愿的限制。为了帮助识别风险较高的患者/幸存者，本系统综述旨在全面审查可能导致淋巴瘤患者/幸存者痛苦的因素。
系统检索了 PubMed 上发表于 1997 年至 2022 年的同行评议原始文章，包含标准关键词“lymphoma”和“distress”。通过叙述性综合，整合了 41 篇文章的信息。
痛苦的一致风险因素包括年龄较小、疾病复发、更多合并症和症状负担。积极治疗以及从治疗到治疗后过渡可能是具有挑战性的阶段。充足的社会支持、对癌症的适应性调整、参与工作以及医疗保健专业人员的支持可能会减轻痛苦。有一些证据表明，年龄较大可能与更大的抑郁有关，生活变化/经历可能会影响个体应对淋巴瘤的方式。性别和婚姻状况不是痛苦的有力预测因素。其他临床、心理和社会经济因素的研究较少或结果存在差异。
尽管一些痛苦因素与其他癌症一致，但仍需要更多研究来确定淋巴瘤患者/幸存者中痛苦的重要因素。确定的因素可以帮助临床医生识别痛苦的淋巴瘤患者/幸存者，并在必要时提供干预措施。该综述还强调了未来研究的方向以及在登记处常规收集痛苦及其因素数据的必要性。
