慢性粒单核细胞白血病（CMML）的预后因素与生存情况
Prognostic factors and survival in chronic myelomonocytic leukaemia (CMML).
作者信息
Stark A N, Thorogood J, Head C, Roberts B E, Scott C S
出版信息
Br J Cancer. 1987 Jul;56(1):59-63. doi: 10.1038/bjc.1987.154.
Ninety-seven cases of chronic myelomonocytic leukaemia (CMML) were examined retrospectively for survival and possible prognostic factors including age, total white cell count, peripheral blood and bone marrow monocyte counts, % double esterase (DE) positive cells in bone marrow and serum lysozyme. Age, absolute monocyte counts and serum lysozyme proved to be significant independent prognostic indicators but Cox model analyses showed serum lysozyme to be the most important factor whether taken as a continuous or discrete (two groups) variable. Twelve cases of second malignancy were found, including 2 cases of multiple myeloma, but this was not significantly greater than expected when compared with an age and sex matched group.
对97例慢性粒-单核细胞白血病（CMML）患者进行回顾性研究，分析其生存情况以及可能的预后因素，包括年龄、白细胞总数、外周血和骨髓单核细胞计数、骨髓中双酯酶（DE）阳性细胞百分比以及血清溶菌酶。结果表明，年龄、绝对单核细胞计数和血清溶菌酶是显著的独立预后指标，但Cox模型分析显示，无论将血清溶菌酶视为连续变量还是离散变量（两组），它都是最重要的因素。发现12例发生第二恶性肿瘤，其中2例为多发性骨髓瘤，但与年龄和性别匹配组相比，这一比例并未显著高于预期。
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