Mufti G J, Hamblin T J, Clein G P, Race C
Br J Haematol. 1983 May;54(1):91-6. doi: 10.1111/j.1365-2141.1983.tb02070.x.
The oncogenic effect of alkylating agents, particularly that of melphalan, has been postulated as the most likely cause of myelodysplastic syndrome (MDS) and acute leukaemia in patients with plasma cell neoplasia. Five patients aged between 69 and 79 years were found to have features of MDS at the time of diagnosis of multiple myeloma. In three of these cases MDS transformed into acute leukaemia. These patients had not received any chemotherapy prior to their presentation. The possible importance of these features is discussed.
烷化剂的致癌作用，尤其是美法仑的致癌作用，被认为是浆细胞肿瘤患者发生骨髓增生异常综合征（MDS）和急性白血病的最可能原因。在诊断多发性骨髓瘤时，发现5例年龄在69至79岁之间的患者具有MDS特征。其中3例MDS转变为急性白血病。这些患者在就诊前未接受过任何化疗。本文讨论了这些特征的可能重要性。
