Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, Goyang-Si, Korea.
Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, Goyang-Si, Korea.
Cancer. 2022 Mar 15;128(6):1230-1241. doi: 10.1002/cncr.34027. Epub 2021 Nov 11.
Metabolic syndrome (MetS) has been identified as a contributor to cancer development. However, reports concerning the association between MetS and colorectal cancer (CRC) have been inconsistent. This study investigated whether MetS, its components, and the number of components increase the risk of CRC.
This was a prospective cohort study of 41,837 participants recruited from August 2002 to December 2014 from the National Cancer Center in South Korea. The participants were followed until December 2017 to identify incident CRC cases. The participants underwent laboratory tests at the baseline. Additionally, a self-administered questionnaire collected information concerning lifestyle and general characteristics at the baseline. A Cox proportional hazards model was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) to explore the association between MetS and its components and CRC risk after adjustments for confounding variables.
In total, 128 incident CRC cases were identified during the follow-up period. An increased CRC risk was found among participants with MetS (HR, 1.63; 95% CI, 1.08-2.44). Additionally, elevated blood pressure (HR, 1.50; 95% CI, 1.05-2.15) and a high fasting glucose level (HR, 1.80; 95% CI, 1.23-2.63) were associated with an elevated risk of CRC. Notably, an increased risk was identified among participants with abdominal obesity coexisting with another component of MetS.
These results suggest that MetS is a risk factor for CRC. Greater emphasis should be placed on the importance of CRC screening among individuals with abdominal obesity coexisting with another component of MetS.
Colorectal cancer (CRC) ranks as the third most common cancer type in terms of incidence. Metabolic syndrome (MetS) has been identified as a contributor to cancer development. However, the association between MetS and CRC remains controversial because of a lack of consistent findings in previous studies. In this study, the National Cholesterol Education Program's Adult Treatment Panel III guidelines are used for the diagnosis of MetS. MetS is found to be a predictor of CRC. Additionally, the importance of CRC screening among individuals with 2 components of MetS should be emphasized.
代谢综合征（MetS）已被确定为癌症发展的一个促成因素。然而，关于 MetS 与结直肠癌（CRC）之间的关联的报告一直存在不一致。本研究旨在探讨 MetS 及其成分，以及成分数量是否会增加 CRC 的风险。
这是一项前瞻性队列研究，纳入了 2002 年 8 月至 2014 年 12 月期间从韩国国家癌症中心招募的 41837 名参与者。参与者在随访期间至 2017 年 12 月被随访以确定 CRC 病例。参与者在基线时进行了实验室检查。此外，通过自我管理问卷收集了基线时的生活方式和一般特征信息。使用 Cox 比例风险模型计算风险比（HR）和 95%置信区间（CI），以探讨在调整混杂变量后 MetS 及其成分与 CRC 风险之间的关联。
在随访期间共发现 128 例 CRC 病例。患有 MetS 的参与者 CRC 风险增加（HR，1.63；95%CI，1.08-2.44）。此外，高血压（HR，1.50；95%CI，1.05-2.15）和空腹血糖升高（HR，1.80；95%CI，1.23-2.63）也与 CRC 风险升高相关。值得注意的是，患有 MetS 且伴有另一种成分的腹型肥胖的参与者的风险增加。
这些结果表明 MetS 是 CRC 的一个危险因素。对于伴有 MetS 且伴有另一种成分的腹型肥胖的个体，应更加重视 CRC 筛查的重要性。
CRC 是发病率排名第三的最常见癌症类型。代谢综合征（MetS）已被确定为癌症发展的一个促成因素。然而，由于以前的研究结果不一致，MetS 与 CRC 之间的关联仍存在争议。在这项研究中，使用国家胆固醇教育计划成人治疗小组 III 指南来诊断 MetS。MetS 被发现是 CRC 的预测因子。此外，应强调在伴有 2 种 MetS 成分的个体中进行 CRC 筛查的重要性。
