State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, China; Shanghai Environmental Protection Key Laboratory on Environmental Standard and Risk Management of Chemical Pollutants, East China University of Science & Technology, Shanghai, 200237, China.
State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Chemosphere. 2022 Mar;291(Pt 2):132837. doi: 10.1016/j.chemosphere.2021.132837. Epub 2021 Nov 8.
Various pollutants are released during pharmaceutical production processes, which is of great concern. Most studies have focused on the terminal treatment results of mixed pharmaceutical wastewater, and further research on wastewater from the production processes is required. This study investigated the wastewater quality indicators, residual antibiotics, and biological toxicity of the wastewater during the production process in a large pharmaceutical producing factory in Northern China. The wastewater contained numerous organic pollutants, with the chemical oxygen demand (COD) values ranging from 2.0 × 10 to 2.6 × 10 mg L and the total nitrogen (TN) values ranging from 1.3 × 10 to 2.0 × 10 mg L. High concentrations of cephalexin and cefradine remained in the wastewater of the production workshop, with the highest concentration of cefradine reaching 1328 mg L. The wastewater from the oxidation and solvent recovery workshops was more toxic to Vibrio fischeri and Daphnia magna than that of other workshops. Moreover, the biological acute toxicity of wastewater was significantly correlated with the concentration of COD and TN (p < 0.01). This study provides new insights into the treatment of antibiotic production wastewater, illuminating the incomplete extraction of products and the significant risk posed by pharmaceutical wastewater to the environment.
各种污染物在药物生产过程中被释放出来，这引起了极大的关注。大多数研究都集中在混合药物废水的终端处理结果上，需要进一步研究生产过程中的废水。本研究调查了中国北方一家大型制药厂生产过程中废水的水质指标、残留抗生素和生物毒性。废水中含有大量的有机污染物，化学需氧量（COD）值在 2.0×10 到 2.6×10mg/L 之间，总氮（TN）值在 1.3×10 到 2.0×10mg/L 之间。生产车间废水中头孢氨苄和头孢拉定的浓度较高，头孢拉定的最高浓度达到 1328mg/L。氧化和溶剂回收车间的废水对发光菌和大型蚤的毒性大于其他车间。此外，废水的生物急性毒性与 COD 和 TN 的浓度显著相关（p<0.01）。本研究为抗生素生产废水的处理提供了新的见解，阐明了产品提取不完全以及制药废水对环境造成的重大风险。
