Sihvonen Aleksi J, Pitkäniemi Anni, Leo Vera, Soinila Seppo, Särkämö Teppo
Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Centre for Clinical Research, The University of Queensland, Brisbane, Queensland, Australia.
Eur J Neurosci. 2021 Dec;54(11):7886-7898. doi: 10.1111/ejn.15524. Epub 2021 Nov 16.
Recent evidence suggests that post-stroke vocal music listening can aid language recovery, but the network-level functional neuroplasticity mechanisms of this effect are unknown. Here, we sought to determine if improved language recovery observed after post-stroke listening to vocal music is driven by changes in longitudinal resting-state functional connectivity within the language network. Using data from a single-blind randomized controlled trial on stroke patients (N = 38), we compared the effects of daily listening to self-selected vocal music, instrumental music and audio books on changes of the resting-state functional connectivity within the language network and their correlation to improved language skills and verbal memory during the first 3 months post-stroke. From acute to 3-month stage, the vocal music and instrumental music groups increased functional connectivity between a cluster comprising the left inferior parietal areas and the language network more than the audio book group. However, the functional connectivity increase correlated with improved verbal memory only in the vocal music group cluster. This study shows that listening to vocal music post-stroke promotes recovery of verbal memory by inducing changes in longitudinal functional connectivity in the language network. Our results conform to the variable neurodisplacement theory underpinning aphasia recovery.
近期证据表明，中风后聆听声乐有助于语言恢复，但这种效应的网络层面功能神经可塑性机制尚不清楚。在此，我们试图确定中风后聆听声乐后观察到的语言恢复改善是否由语言网络内纵向静息态功能连接的变化所驱动。利用一项针对中风患者的单盲随机对照试验（N = 38）的数据，我们比较了每日聆听自选声乐、器乐和有声读物对语言网络内静息态功能连接变化的影响，以及它们与中风后前3个月语言技能和言语记忆改善的相关性。从中风急性期到3个月阶段，声乐组和器乐组中包含左侧顶下区域的一个簇与语言网络之间的功能连接增加幅度大于有声读物组。然而，只有在声乐组的簇中，功能连接增加与言语记忆改善相关。这项研究表明，中风后聆听声乐通过诱导语言网络中纵向功能连接的变化促进言语记忆恢复。我们的结果符合支持失语症恢复的可变神经移位理论。
