Blasi Valeria, Rapisarda Laura, Cacciatore Diego Michael, Palumbo Edoardo, Di Tella Sonia, Borgnis Francesca, Baglio Francesca
IRCCS Fondazione Don Carlo Gnocchi Onlus, Milan, Italy.
Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy.
J Neurol. 2025 Apr 9;272(5):329. doi: 10.1007/s00415-025-13048-6.
Music- and dance-based rehabilitation has gained prominence in promoting social engagement and improving motor, cognitive, and mood domains in individuals affected by different neurological disorders.
This systematic review aims to synthesize existing evidence from randomized controlled trials (RCTs) investigating neuroimaging-based structural and functional neuroplasticity following music- and dance-based interventions among people with neurological disorders.
Literature research was performed using PubMed (MEDLINE), Scopus, and Web of Science (WOS). A multidimensional approach was employed to assess the efficacy of music- and dance-based interventions, integrating neuroimaging and clinical assessments.
Out of a total of 2247 papers reviewed, 20 RCTs met the inclusion criteria for this review, with a total of 718 subjects. Among them, 88% underwent a neuroimaging investigation to evaluate structural or functional neuroplasticity. Six studies involved dance-based interventions, while 14 examined music-based rehabilitation. These interventions targeted cognitive, motor, and mood impairments in people at risk of dementia or with neurological disorders including Huntington's Disease, stroke, traumatic brain injury, spinal cord injury, and disorder of consciousness.
Overall, the selected studies demonstrated significant effects on behavioral and neuroimaging outcomes, showing structural and functional changes in critical areas for perception and memory in patients at risk of dementia, as well as in regions essential for language processing, emotional regulation, and motor control in patients with acute and chronic stroke. Nevertheless, several biases were identified, specifically related to neuroimaging biomarkers, such as a lack of baseline and between-group comparisons and a lack of prior registration of neuroimaging biomarkers investigated. The protocol of this review was registered in the International Prospective Register of Systematic Reviews (PROSPERO), with registration number CRD42024574754.
基于音乐和舞蹈的康复疗法在促进社交参与以及改善受不同神经系统疾病影响个体的运动、认知和情绪领域方面已变得日益重要。
本系统评价旨在综合来自随机对照试验（RCT）的现有证据，这些试验研究了神经系统疾病患者在基于音乐和舞蹈的干预后基于神经影像学的结构和功能神经可塑性。
使用PubMed（MEDLINE）、Scopus和科学网（WOS）进行文献研究。采用多维度方法评估基于音乐和舞蹈的干预效果，整合神经影像学和临床评估。
在总共审查的2247篇论文中，20项RCT符合本综述的纳入标准，共有718名受试者。其中，88%接受了神经影像学检查以评估结构或功能神经可塑性。六项研究涉及基于舞蹈的干预，而十四项研究考察了基于音乐的康复。这些干预针对有痴呆风险或患有神经系统疾病（包括亨廷顿舞蹈症、中风、创伤性脑损伤、脊髓损伤和意识障碍）的人群的认知、运动和情绪障碍。
总体而言，所选研究显示出对行为和神经影像学结果有显著影响，表明有痴呆风险的患者在感知和记忆关键区域出现结构和功能变化，以及急性和慢性中风患者在语言处理、情绪调节和运动控制所必需的区域出现变化。然而，发现了一些偏差，特别是与神经影像学生物标志物相关的偏差，例如缺乏基线和组间比较以及所研究的神经影像学生物标志物缺乏预先注册。本综述方案已在国际系统评价前瞻性注册库（PROSPERO）注册，注册号为CRD42024574754。
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